Talk:Pyrimidine dimer

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Proposed merger[edit]

I'm proposing that Thymine dimer be merged into this page. All the information on the thymine dimer page is pertinent for other pyrimidine dimers. While thymine dimers are the most commonly formed, CT dimers and CC dimers are also formed at significant rates [1], and the CC and CT dimers are actually more likely to result in mutations due to the "A rule" that causes As to be inserted when the template is doubtful[2]. I can add the material from Thymine dimer to this page and then add a discussion based on the references above, and I think it will be more informative than having the two articles separate. Agathman (talk) 16:00, 29 May 2009 (UTC)

Okay, I've set up a draft of the proposed new Pyrimidine Dimer page here: User:Agathman/CPDs_Working_Page. There has been no comment since the merger proposal went up, almost 3 months ago, so I'm about ready to replace the Pyrimidine dimer page with my draft and replace the Thymine dimer page with a redirect to that one. If anyone cares, please say so soon.
Sounds good. I will rescue the highly chemical bit abuot cyclobutanes. Thymine dimer is not very impressive as it stands, so your work is a real improvement.--Smokefoot (talk) 16:23, 16 August 2009 (UTC)




Although this article is about a technical subject, the lead should be made easier to understand. For example, the word “translesion,” although correct, is not in the dictionary. Bwrs (talk) Bwrs (talk) 03:34, 1 December 2009 (UTC)

Not 6-4 and left handed DNA[edit]

In the figure illustrating the types of dimers, 6-4 photoproduct is shown incorrectly. What is shown is a so-called "spore photoproduct" (http://www.photobiology.com/photoiupac2000/nichol/index.htm). The structure of 6-4 is quite different (http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed&part=A3935, Fig. 15.2) —Preceding unsigned comment added by 89.251.107.24 (talk) 11:44, 12 June 2010 (UTC)

The SP product is okay according to 2006 paper by Buis et al ... doi:10.1074/jbc.M603931200. Your ref (http://www.photobiology.com/photoiupac2000/nichol/index.htm) gets its structure for Figure 15.2 from Taylor et al J Am Chem Soc. 1987; 109: 2834–2835, which might be obsolete. Medical sources occasionally are way behind on their chemistry.--Smokefoot (talk) 01:24, 16 November 2010 (UTC)

The image 'DNA_UV_mutation.svg‎' shows a left-handed DNA, it should be a right handed DNA. This a fundamental mistake.

  1. ^ Mouret, S; Baudouin, C; Charveron, M; Favier, A; Cadet, J; Douki, T (Sep 2006). "Cyclobutane pyrimidine dimers are predominant DNA lesions in whole human skin exposed to UVA radiation" (Free full text). Proceedings of the National Academy of Sciences of the United States of America 103 (37): 13765–70. doi:10.1073/pnas.0604213103. ISSN 0027-8424. PMC 1564232. PMID 16954188. 
  2. ^ Brash DE, Rudolph JA, Simon JA, et al. (November 1991). "A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma". Proc. Natl. Acad. Sci. U.S.A. 88 (22): 10124–8. PMC 52880. PMID 1946433.