|WikiProject Molecular and Cellular Biology||(Rated Start-class, Low-importance)|
|WikiProject Autism||(Rated Low-importance)|
Amino Acid sequence listed C -> N termini?
The amino acid sequence of secretin is given here starting at the C terminus and ending at the N terminus, against normal convention to write the sequence from N->C. Is entire sequence backwards? Or did original author/ editor simply switch the COOH/NH2 end labels? —Preceding unsigned comment added by 18.104.22.168 (talk) 03:10, 2 November 2009 (UTC)
- Good catch. The sequence is written in the correct N- to the C-terminus direction (see UniProt P09683, residues 28–54), but the CO2H/NH2 end labels were reversed from what they should be. This error has now been corrected. The confusion may have been caused by the fact that the C-terminus is amidated (CO2H → CONH2). Boghog (talk) 06:35, 17 September 2010 (UTC)
- I believe it is typical to represent c-terminal amidation by "-NH2" rather than "-CONH2" as this would imply that the carbonyl group is not part of the residue's definition. I have changed this. Please advise if this is incorrect. For example, see "davalintide" in INN list 101. http://www.who.int/medicines/publications/druginformation/innlists/PLFinal101.pdfPeryeat (talk) 21:19, 14 May 2013 (UTC)
Secretin and gastrin inhibition
Pretty sure secretin does not DIRECTLY inhibit gastrin secretion (otherwise, how do you explain ZES which is essentially an XS of G cells?). Instead, its inhibitory function is mediated via somatostatin. Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC370446/ Normally, somatostatin inhibition exceeds the enhancement of gastrin secretion by secretin, but in ZES, this goes out of whack because of the XS of G cells relative to D cells, hence an upward elevation in gastrin with secretin stimulation in ZES. I don't know how to word the above in a concise format.
Source: my GI professor, but I'm sure there are other sources out there e.g. http://www.ncbi.nlm.nih.gov/pubmed/2565843
Secretin to Treat Autism
The article says that secretin has been proposed as a possible treatment for autism based on a hypothetical gut-brain connection, but there's more to it than that. Secretin has been demonstrated to increase activity in the amygdala, a part of the brain dysfunction of which is linked to autism. http://www.autism.com/ARI/newsletter/182/page2.pdf