Talk:Self-experimentation in medicine
|WikiProject Medicine||(Rated Start-class, Low-importance)|
Does the Implant Technology Case Belong in This Article
Flu (Salk), Polio (Salk), HIV (Zagury) Vaccines
I don't know what or how much should be in the main article.
From: Wall Street Journal, 3/19/87 "AIDS Scientist's Self-Inoculation Sparks Debate" By Marilyn Chase, Staff Reporter of The Wall Street Journal
"A report that French scientist Daniel Zagury made himself the first human subject to receive an experimental AIDS vaccine has electrified the scientific community, but left it divided as to whether the action was heroism or folly. [...]"
The WSJ article also mentions that Jonas Salk injected himself twice (with experimental flu vaccine in 1942 and polio vaccine in the 1950s) before large scale testing began on others. AdderUser (talk) 23:07, 2 January 2008 (UTC)
Bio-absorbable Sutures: Baptist (W. R. Grace and Co.)
Quoted from: "Poly(hydroxyalkanoates): Biorefinery polymers with a whole range of applications. The work of Robert H. Marchessault" by William J. Orts, Geoffrey A.R. Nobes, Jumpei Kawada, Sophie Nguyen, Ga-er Yu, and François Ravenelle, Can. J. Chem. 2008, 86(6), 628-640.
page 630, column 2: "For example, in one verified story (36), Baptist wanted to convince the world that PHB could be applied as a bio-absorbable suture. He created a PHB fiber, slashed his own arm with a scalpel, and then sutured the cut with this fiber." AdderUser (talk) 17:04, 23 May 2008 (UTC)
Self-surgery: Evan O'Neill Kane
"In 1921, Evan O'Neill Kane of Kane, Penn., wanted to prove that ether—the primary general anesthetic at the time—was being used far too often when less-dangerous local anesthetics could be substituted. As his test case, the good doctor used himself, removing his own appendix using only local anesthetic by propping himself up on the operating table with a mirror over his abdomen. With three other doctors in the operating room as backup, Kane made the large incision needed to remove the appendix and his assistants sutured him up. (This was before new techniques allowed doctors to make small 'Band-Aid'-size incisions for appendix removal). The doctor recovered nicely. Then, in 1932, at age 70, Dr. Kane performed an even more complicated surgery on himself to repair an inguinal hernia. Because of the close proximity to the femoral artery, it was a particularly delicate operation—Kane performed it in just under two hours. Reportedly, he was relaxed and joking even as he sutured within millimeters of the important blood vessels." Quoted directly from: "Six Surgical Miracles: Some of the more amazing and unusual operations of modern times." By Susanna Schrobsdorff, Newsweek Web Exclusive, Jun 16, 2008; Updated: 11:01 a.m. ET Jun 16, 2008, Link. AdderUser (talk) 07:17, 17 June 2008 (UTC)
Earliest Example? Daniel, 605 BCE
In 605 BCE, Daniel and several other Jewish captives of Nebuchadnezzar were offered positions in the government and a diet of the king's own rich meats and wines. Refusing to violate the Jewish dietary laws, they declined the food and asked for a diet of legumes and water instead. The officials had a serious concern that such a limited diet might be unhealthy so Daniel offered to conduct a trial. He conducted a diet study as a "self-experiment" (along with 3 others, Hananiah, Mishael, and Azariah). After 10 days on the abstemious diet, the subjects appeared even healthier than the controls eating the king's food and were allowed to continue. Details of the Bible stories can be found in Wikipedia and on the web. There is an interesting evaluation in the context of clinical trials and program evaluations here: David E.K. Hunter, "Daniel and the Rhinoceros", Evaluation and Program Planning Volume 29, Issue 2, May 2006, Pages 180-185 (Program Capacity and Sustainability). Link - DOI AdderUser (talk) 21:38, 21 June 2008 (UTC)
I recall reading years ago that the use of a fibre-optic endoscopes for examining heart valves was first tested by self-experimentation, but I can't recall the reference or any of the details. Does anyone have information on that? --Tedd (talk) 18:02, 28 March 2009 (UTC)
Giles Brindley and ED
Giles Skey Brindley self-experimented by injecting vasoactive agents (papaverine, phentolamine, and others) into his own corpus cavernosum (penis) to induce an erection. His results were startlingly presented in a famous 1983 talk at the Urodynamics Society meeting in Las Vegas. See:
Laurence Klotz. "How (Not) to Communicate New Scientific Information: A Memoir of the Famous Brindley Lecture." BJUI, 2005, 96(7), 956-957. (BJUI ~ British Journal of Urology International.) AdderUser (talk) 17:55, 24 January 2012 (UTC)
I added Steve Ludwin to snakevenom self-experimenters and changed the sections name to snakevenom because the experiments where done in controlled doses of snakevenom sometimes much lower than a normal dose in snakebite. My edit was reverted and I want to ask why? --Custoo (talk) 00:57, 4 July 2013 (UTC)