|WikiProject Physiology||(Rated Mid-importance)|
|WikiProject Molecular and Cellular Biology|
Testing for albumin loss via the kidneys
The following fragment is not a sentence but I don't know enough about the subject matter to correct. "In some diseases including diabetic nephropathy, a major complication of uncontrolled diabetes."
- I have corrected the sentence to something that makes a bit more sense. English is not my first language, however. So if there is a mistake in the grammar or phrasing, please go ahead and correct it. C3045051 01:41, 28 October 2006 (UTC)
Definition of albumin
(moved from talk:Albumins by habj, 20:36, 2 May 2006 (UTC)) Most of what we see on this page is Human Serum Albumin. In the most general definition, albumin is any protein that is water soluble, moderately soluble in concentrated salt solutions, and is heat coagulable. Bovine Serum Albumin is a commonly used protein in research. Of course, there are many more. Novangelis 19:19, 7 February 2006 (UTC) I split off the human specific data to a new article Human serum albumin. I'll come back and do touch-ups on both halves in March, after I've given people a chance to look over what I have done and I've had a chance to review my notes. Novangelis 20:42, 7 February 2006 (UTC)
- I have moved things about, see below. // Habj 20:36, 2 May 2006 (UTC)
Merge human serum albumin and bovine serum albumin into this article?
I have been rearranging a bit, to make the content of the pages more logical with the title and also created a disambig page at albumin. This article is mainly about medical aspects, so either content needs to be moved to the human page or this one merged here. I suggest we merge both human serum albumin and bovine serum albumin into this article. They are very different, but it is an excellent opportionity to collect diverse info from different fields into one article, to cover different aspects of the topic. Neither of the species-specific is very large, no do I expect they will be. // Habj 20:32, 2 May 2006 (UTC)
- Don't Merge. The problem with merging is that these are just two specific instances of many. It's a tough call on how "humanocentric" we should be, and how important human specific data is in the serum albumin discussion. —Preceding unsigned comment added by Novangelis (talk • contribs) 05:20, 6 May 2006
- If human and bovine serum albumin are truely each species version of the same protein, I would vote to merge. Important differences can easily be pointed out. BUT, I'm really against refering to either of these as 'albumin'. Albumin is a class, not a particular protein. ike9898 22:19, 18 May 2006 (UTC)
As I get more Wiki experience, I'm thinking in terms of eliminating all sequence data except links, and merging species specific data into sections and subsections under serum ablumin. Novangelis 18:29, 16 May 2006 (UTC)
- As I understand it, serum albumin in different species are "each species version of the same protein" - yes. When I say "they are very different" above, I mean that the articles are very different since we often use BSA in the lab. // Habj 00:55, 26 May 2006 (UTC)
- BSA is famous for it’s usage in molecular biology as protein standard and for blocking western blots. This field of application has nothing to do with the medical aspects of HSA. From my point of view this articles should NOT be merged. Steve42
As a protein scientist working with human serum albumin, I feel that its full name should be used for the article containing the most information about the protein. Searches for albumin, serum albumin and HSA should all point to it. //Sara
As a Clinical Biochemist, I am finding it very hard to follow links that point to 'albumin', 'serum albumin' and 'human serum albumin'. It's obvious that other authors/editors aren't aware that one or another article exists, so that important information has been put in one or another, but not in both. I vote to merge,
but if not then 'serum albumin' should be stripped down to its essentials and a link provided at the top to 'human serum albumin' and 'bovine serum albumin'. Alternatively (at the risk of being called "humanocentric") merge 'human serum albumin' into this and provide a link at the top to 'bovine serum albumin'. Scolaire 15:04, 12 July 2006 (UTC)
On reflection, another alternative is to have two articles entitled 'Serum albumin' and 'Serum albumin (laboratory reagent)'. All information relating to physiology, pathology and measurement of albumin, be it in humans, cows, horses or dogs, should be cut and pasted into the first article. Both 'Bovine serum albumin' and 'Human serum albumin' should be moved to the second, and contain all information relating to the use of BSA and HSA in protein, molecular biology and other laboratories. Scolaire 18:46, 13 July 2006 (UTC)
- Merge serum albumin and human serum albumin, remove medical info from albumin. Agree with Scolaire that editors are obviously not aware of the all the articles - info is either duplicated across articles or is included in one article but not others. It's very untidy and confusing. Arripay (talk) 23:43, 8 July 2013 (UTC)
Do not merge. I see not why they should be merged. There is probably plenty about each type of serum albumin to make a good article each. the ambiguation page albumin already differs between human serum albumin and bovine serum albumin. Any common characteristics in the serum albumin eg also any conserved amino acid sequence etc. Benkeboy 13:59, 7 September 2006 (UTC)
Merge. i) Human serum albumin is an instance of serum albumin; its function, physiology and associated pathologies are the same in all species. In case there is a known and documented difference between species, it should be highlighted in the common article. ii) Bovine Serum Albumin could also be merged into a subsection of the common article, to the extent that its extensive use in laboratories results from the general properties of serum albumin as well as its ease of purification. jean-philippe, chem grad student 220.127.116.11 01:37, 18 November 2006 (UTC)
- No merger - Albumins are albumins, serum albumins are a fraction of albumins (water soluble proteins characterzed in plants in 1895 by Osborne T. You also do not merge house and house keeper - Steen Petersen, Copenhagen
They are not the same thing, do not merge them.
- The four articles in question form a hierarchy:
- Albumin – the family of proteins that share common fold (3D structure) (Pfam PF00273)
- In this particular case, I think there is enough specific material about each subject to justify four separate articles. However they do need to be cleanup somewhat to minimize overlap. I have made a few edits in this direction and I will make additional edits as I find time. Boghog (talk) 07:43, 22 May 2010 (UTC)
The article as currently written reflects dogma: that the negative charge of the glomerular basement membrane created permselectivity with respect to albumin. See this article in Kidney International for a very different take on the topic: LM Russo, et al: The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: Retrieval is disrupted in nephrotic states Kidney International (2007) 71, 504–513 —Preceding unsigned comment added by Gaff (talk • contribs) 23:57, 16 October 2007 (UTC)
Albumin in the brain
A 2003 Swedish study found that serum albumin leaks through the blood-brain barrier in individuals (of rats) exposed to mobile phone electromagnetic radiation. This is a topic of the article on Mobile phone radiation and health. I figure it ought to be mentioned that serum albumin naturally does not find its way into brain tissue. Perhaps this could be discussed here so that a citation for such a statement could be presented before this information is entered into that article. __meco (talk) 08:44, 8 March 2008 (UTC)
What kinds of "substances" does it carry? this section really could be beefed up by someone more knowledgeable than I. —Preceding unsigned comment added by 18.104.22.168 (talk) 20:29, 24 October 2008 (UTC)
Albumin is a general transporter in serum, it carries a large variety of molecules. I suggest using:
1. Burtis C, Ashwood E. 2001. Tietz Fundamentals of Clinical Chemistry. 5th edition. Philadelphia, Pannsylvania: Saunders. 1092 p.
2. Nelson D, Cox M. 2005. Lehninger's Principles of Biochemistry. 4th ed. New York: W. H. Freeman and Company. 1300 p.
alpha helix - beta sheet
I noticed that the "Structure" section of the article contains the following statement:
"The general structure of Albumin is characterized by several long β (beta) sheets..."
However, the crystal structure of human serum albumin clearly shows that it is composed of almost entirely alpha helices, therefore I have changed the text to fit the data. This is my first time editing a Wikipedia page, so please excuse my lack of knowledge about proper etiquette. 22.214.171.124 (talk) 02:49, 8 September 2010 (UTC)