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|WikiProject Medicine / Toxicology||(Rated Start-class, Low-importance)|
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I recall reading that NaN3 can also be obtained by oxidizing hydrazine with sodium nitrite.
- NO2– + N2H4 → N3– + 2H2O
If I can find a reference for this, I will post it to the article. Karlhahn 16:43, 22 August 2006 (UTC)
It seems to be a normal thing to dilute antibodies in, why is this? --David Munch 14:24, 14 June 2007 (UTC)
http://en.wikipedia.org/w/index.php?title=Talk:Sodium_azide&action=edit Editing Talk:Sodium azide - Wikipedia, the free encyclopedia
Sodium Azide is used as a preservative in solutions containing antibodies.
Can there be something in the introduction that says it is also known as heavy sodium? I was searching for heavy sodium and was referred to this article which was 100%.
Half life in Water?
I read on here that NaN3 will slowly convert to HN3. I looked on the internet and it seemed like HN3 is a gas? Also, the wiki page on HN3 makes it seem like it has properties are similar to NaN3. I am asking because we have a 1 molar solution of this dissolved in water that has been around since 2004 or so. I was curious how fast it degrades and if the solutions are still good. We are using it in a protease cocktail to preserve skinned (demembranated) straited muscle. Also, if it does go bad, how long would a 1M solution last at room temp? Thanks a lot, Rjkd12 15:29, 11 October 2007 (UTC)
- I revised that misleading statement. Prototonations virtually do not require time, the conversion ot HN3 is instantaneous but fortunately proceeds to a limited extent. --Smokefoot 18:11, 11 October 2007 (UTC)
Thanks a lot for the response. I'm still curious its 1/2 life in water. I tried looking it up with sigma, but none of the pages talk about a 1/2 life. As I said earlier I have some from around 05 that is 1 molar and want to know if its ok. A lot of things say its not stable in water due to the conversion, but you claim thats to a limited extent. Also, if it is to a limited extent, does uncapping and recapping the same container, which allows fresh air to get in there keep the equilibrium down so it continuously converts? Thanks a lot, I appreciate everything. Also, if you have a 1/2 life a source would be very helpful so I can put it in my lab notebook. Thanks again, Rjkd12 15:24, 29 October 2007 (UTC)
The article states that: "No toxicity has been reported from spent airbags." But right after it says: "The toxicity of this substance led to an unfortunate incident in early 2011 when a driver inhaled the chemical from a punctured airbag after a road traffic incident" Shouldn't the first sentence be removed? Sensnom (talk) 17:53, 26 June 2012 (UTC)
Where is value for 'lethal dose for an adult human' coming from?
The MSDS gives different LD50s depending on route of exposure and species. "0.7g" is not specifically named; where exactly is this figure coming from? You need to state which LD50 you are using and its value. Which species was tested? Via which route were they exposed? I know I'm being fairly picky, but there is a difference between eating chocolate and injecting it.
Also, while the average adult weight is illustrative, this excludes children and over-/under-weight or short/tall people (I'm reasonably certain that they die too, but I'm not going to test this). It might not represent the average man or women very well either. This doesn't necessarily matter; more importantly, this is misleading if you don't mention that the size of the dose is related to body mass. Sure, have an average or set of averages for an at-a-glance impression, but name the LD50, not just the basic MSDS.
The oral LD50 for mice is 27mg/kg of body weight. The average adult is [apparently] around 70kg, which makes 1.89g. Even a small adult, eg me (50kg), will have a corresponding dose of 1.35g. 0.7g seems a very low figure to get from the MSDS sheet; about half what I'd expect the oral dose to be.
The skin LD50 for rabbits is around the same at 20mg/kg, so this isn't much better. The only other things I see on the MSDS sheet are airborne exposure limits - about 0.3mg/L - but these don't describe fatal doses.
It might be better to remove this value if it isn't explained in text or a footnote; anyone else want to have a go at calculating it? — Preceding unsigned comment added by 126.96.36.199 (talk) 21:26, 6 March 2013 (UTC)