Talk:Thymosins

From Wikipedia, the free encyclopedia
Jump to: navigation, search
WikiProject Molecular and Cellular Biology (Rated Start-class, Low-importance)
WikiProject icon This article is within the scope of the WikiProject Molecular and Cellular Biology. To participate, visit the WikiProject for more information.
Start-Class article Start  This article has been rated as Start-Class on the project's quality scale.
 Low  This article has been rated as Low-importance on the project's importance scale.
 

This page is so unorganized. Looks like someone with a ton of knowledge of the subject just went off on a physiological stream of consciousness. —Preceding unsigned comment added by 66.66.254.174 (talk) 18:07, 28 May 2008 (UTC)

This article badly needs wiki-formatting ...Still needs it. I'm not fluent in the use of templates to indicate this on the article itself, would appriciate if a wiki guru could do that.

It also needs to

1) distinguish the un-related alpha- and beta- thymosins and 2) confront the surprising duality of hormone-like (presumed extracellular) and actin-sequestering activities.Gbaa01 20:57, 19 February 2007 (UTC)

I contemplate starting a new page for thymosins, in order to take on board the existence of alphas and betas. I would be grateful for comments from anyone watching this page. Jgedwards (talk) 16:48, 19 March 2010 (UTC)

Plagiarized text[edit]

The paragraph beginning with "The promise of repairing sun parched aging skin is alluring" didn't look right, so I checked online and found it was largely copied from here: http://www.lef.org/magazine/mag2002/feb2002_report_tb4_01.html 24.7.127.106 07:27, 13 September 2007 (UTC)

No further comments, so I've removed it. The article does still need more work, For example, the text refers to figures. Does this imply all that text was borrowed from somewhere else too? I dunno. 67.164.125.7 (talk) 06:06, 2 February 2009 (UTC)

Thymus[edit]

please mention that it is produced by the thymus gland, along with thymolin and thymopoetin. also of course, it needs some spacings, paragraphs and pictures to be more presentable... Andrei A A (talk) 17:44, 8 June 2009 (UTC)

History[edit]

Beyond a concerted "Huh?" for the impenetrable biospeak, I'd want to know when thymosin was discovered, by whom, & at what institution... I also wonder, given refs to figs not present, if more than the already-deleted text wasn't plagiarized from somewhere... TREKphiler hit me ♠ 03:32, 2 October 2009 (UTC)

illogical, irrelevant, undocumented[edit]

The entire second part of this article, beginning with "Skin is the largest organ of the body, which makes up 16% of total body weight" and ending with " as seen in the following experiments" is illogical, irrelevant, and undocumented. It reads as if it was copied from the intro of a research paper. There are no references for any of the statements, no documentation at all. And it makes no sense -- if thymosin prevents polymerization of actin, how can it promote epithelial motility? You'd expect just the opposite! —Preceding unsigned comment added by GeorgeAndGracie (talkcontribs) 22:00, 4 February 2010 (UTC)

Response to criticisms[edit]

I have started dealing with the multiple issues raised by this page, beginning with brief leader and adding structure and citations. It is work in progress. much of the text now in the sections "Actin Binding" and "Other biological activities" is indeed plagiarised from the cited textbooks and requires to be rewritten from scratch. I hope the questions raised under headings Thymus and History are satisfactorily answered. Jgedwards (talk) 19:38, 23 March 2010 (UTC)

On removing more plagiarised material under Actin Binding, I thought the references to ATP- and ADP- actins are too deep, unless explained. Similarly, the details of competition with profilin. Guess these aspects may underly the "impenetrable biospeak" referred to above? Also the control of microfilament assembly is far more complex than this account suggested. Jgedwards (talk) 11:46, 25 March 2010 (UTC)

Plural versus singular[edit]

On starting the major re-write of this page (See "Response to criticisms" above) I altered the title to the plural "Thymosins". This was chiefly driven by the need to clarify that the article deals with both alpha and beta thymosins. I would be interested to see the reasoning behind reversion to singular, but in the absence of reasoned justification will undo it. Jgedwards (talk) 08:23, 13 August 2010 (UTC)

Heya, You're entirely right. I'd misread the focus of the article and as you say, it's about a group rather than a single protein. I've now changed the page back. Thanks for pointing it out, and sorry for rushing in like that >.< Abergabe (talk) 08:32, 13 August 2010 (UTC)

Growth[edit]

Re the addition stating that growth in years 10-13 is controlled by "thymosin" (14:52, 17 January 2011 Anuprasadibt) I do not believe there is any evidence for this assertion. Also "thymosin" unspecified as to which, is pretty meaningless. Any addition along these lines would require citation of a reliable source and specification of which thymosin. I will therefore delete this - though of course am happy to discuss further. Jgedwards (talk) 15:45, 17 January 2011 (UTC)