Talk:Thyrotropin-releasing hormone

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Strange sentence[edit]

"The presence of TRH can also be detected in other parts of the brain, such as the gastrointestinal system and pancreatic islets." Does that make sense to anyone else? Aren't the pancreatic islets in... well... the pancreas, and not the brain? Am I missing something totally obvious here? Semiconscious 11:05, 19 December 2005 (UTC)

Heh. Nope, that doesn't make any sense to me either. Hopefully my change fixed things. --David Iberri (talk) 15:46, 19 December 2005 (UTC)
Awesome. That seems more like how I learned it. Semiconscious 00:00, 20 December 2005 (UTC)

I think, the chemical structure of TRH is not correct. Please check the nitrogen atoms in the ring on the left side Michael Temerowski

I'm sorry, but what exactly is wrong with it? Fvasconcellos 13:08, 14 March 2007 (UTC)

Thyrogen is recombinant human TSH not TRH129.215.239.28 17:35, 1 November 2007 (UTC)


Secondary or Tertiary[edit]

I came across this page while researching hypothyroidism. The main Wikipedia Hypothyroidism page says that TRH testing is done for tertiray causes of hypothyroidism, however this page says, "A TRH test may be indicated if secondary hypothyroidism is suspected." I'm not an expert in this field at all, but I just thought I would bring this up so that someone who is an expert could evaluate the apparent discrepancy. Thanks. Blaklite (talk) 18:29, 19 April 2008 (UTC)

Most hypothyroidism associated with the pituitary is accompanied by a broader defect in the gland (e.g. tumor) that is fairly obvious, which makes the TRH test unnecessary for making the diagnosis. There are some uncommon isolated TSH deficiences, but the TRH test distinguishes tertiary from secondary (i.e. whether the source of the problem is the hypothalamus or the pituitary), so it is in effect a test for both: if administration of TRH results in an increase of TSH and T3/T4, the problem is in the hypothalamus (tertiary); if administration of TRH does nothing, the problem is in the pituitary (secondary). Unless there are concurrent deficiencies, or another hormone that exerts negative feedback on the pituitary is counteracting the stimulatory effect of TRH, but that's going a little too far in-depth.

Also, this may be a confusion between terminologies: standard terminology (at least, in the United States) includes any non-thyroid etiology as secondary. Thus, what is described as "tertiary" hypothyroidism in the main article would be considered "secondary" where this understanding of secondary predominates. In either case, it looks like both articles are correct, if perhaps a little confusing. 139.52.180.78 (talk) 15:50, 13 January 2011 (UTC)

Synthesis section[edit]

This section is incorrectly named - also it is poorly written. Please consider rewriting the section.

AriaNo11 (talk) 18:46, 11 January 2011 (UTC)