Talk:Toxicity

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==Acute toxicity table==is awesome


The note below the table indicates "expected values" for undefined values. Its confusing, doesn't make sense, and has no citation. I'd remove it but I wondered if anyone else had an opinion on this.

There[edit]

There are toxins, mutagens, tetragens... classified according to their impact on cells. Colloquially, the latter are considered toxic, so they should be linked here too.

The unsigned comment above was the original message on this page, placed by 142.177.77.65 on 18 January 2003

What is the derivation relating to the idea of the Saftey Factor?[edit]

IN article "Toxicity" - refered in paragraph starting: Toxicity can be measured by the effects on the target (organism, organ, or tissue). a concept is refered to. The saftey factor is brought up in my Toxicology course in college when the NOEL concept is explained. NOEL being the No Observable Effects Limit, is then divided by a safety factor (i.e 100).


Is this to put representation into numerical form to reflect the results of the toxicity study of a particular substance? So would the Safety Factor really be a percentage type figure, or is it more focused on why the result was returned. i.e - factors such as, how the organism metabolised the substance, how the dose was inflicted upon the organism, how reliable the substance is at reacting in an organism, etc. If the latter is the case, this would mean that no 'universal saftey factor' would exist for a substance because all organisms are different from eachother both in families and not in families.

Kthx, please respond with an answer that states: Saftey Factor is used when.... Saftey Factor is applied to return what exactly when relating to a NOEL graph.

A Safety Factor is an arbitrary number applied as a divisor "just in case" - after all available quantitative adjustments and calculations as a way to be more comfortable that a suggested acceptable level would not be likely to produce a toxic effect in humans. There used to be a broad agreement in the toxicology community as to what safety factor should be applied. The agreement seems to have broken down over the last couple of decades, with more variation in what is proposed based on who is speaking and what the toxic effect is being examined. Pzavon 02:39, 6 January 2007 (UTC)

See added text in article. OccDoc 23:09, 6 April 2007 (UTC)

Plant toxicity to pets[edit]

I don't know if this is the proper place to ask this, but I'm looking for a page about the various toxicities of plants to pets. If there is no such page, or no such information on wikipedia, what would we need to do to get such a page started? I don't know enough about it to do it myself, but I think it's something that's pretty important. Question posted 2 July 2007 by User:Ishmayl

Water[edit]

Water can kill (e.g. 20 literes) but not by toxic effect. It can kill by physical effect. Otherwise the notion of toxicity loses it's sense because in this way every substance in the Universe will be a toxine. And also a brick fallen down on a head and killing by strike will be also a toxine.

Toxine effects in different ways: 1. Direct toxic influence 2. Influence for separate organs 3. Influence for separate cells

Also toxin dose is relatively small in comparison to the body weigth. —Preceding unsigned comment added by 95.25.100.169 (talk) 21:21, 15 July 2010 (UTC)

See The dose makes the poison, and Water intoxication. WhatamIdoing (talk) 03:56, 7 January 2011 (UTC)

Radioactive Toxicity[edit]

Surely there should be a section on Radioactive Toxicity.

"Toxicity is the degree to which a substance can damage an organism." Plutonium is a substance and its radioactivity can damage organisms. At the very least there should be a pointer to whatever article is appropriate, but there is not an immediately obvious article that I could find, except the empty hold in this one. Hu (talk) 10:59, 3 April 2011 (UTC)

introduction[edit]

What is a non-living organism? --David Munch (talk) 17:51, 1 January 2012 (UTC)

(ditto) Given a non-living organism (i.e. a dead organism), how can we judge degree of toxicity? Certainly LD50 is not useful. A non-living organism cannot be 'harmed' and there is little distinction between being dead and really dead. Perhaps there is a protocol to identify toxicity based on test effects on preserved tissue specimens. I would recommend removing this text unless there is a technical reference document that spells out what is meant by toxicity in regards to 'non-living organisms'. kradak (talk) 13:10, 14 February 2012 (UTC)

I agree 101.171.42.157 (talk) 05:01, 20 May 2012 (UTC)