Talk:Transmembrane protein

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I made a few changes. A lot of things should be described here. Biophys 05:19, 4 November 2006 (UTC)

Work in progress...Biophys 07:13, 5 November 2006 (UTC)

I included structural and functional classification of TM proteins. Please correct me if I am wrong somewhere. Biophys 00:40, 7 November 2006 (UTC)

I included first version of "Stability and folding" section. More work is needed. Biophys 01:40, 13 November 2006 (UTC)

Structures of several transmembrane proteins retracted[edit]

See A Scientist's Nightmare: Software Problem Leads to Five Retractions. So, I have to change this article accordingly. Biophys 20:30, 2 January 2007 (UTC)

Alpha-helical proteins in outer membranes[edit]

In fact, there are alpha-helical proteins in outer membranes, like Stannin and certain lipoproteins.Biophys (talk) 14:57, 9 September 2008 (UTC)


Three different transmembrane proteins that completely span their membrane. The membrane is represented in light brown.

Complete non-scientist here. Reading the first sentence of this article, I'm wondering what "spans" means in the statement, A transmembrane protein is a protein that spans the entire biological membrane. Does it mean that this protein is a component of a membrane and is present throughout all regions of the membrane, or is this protein a separate thing from a membrane that may be found on either side of the membrane? Or something else? (Or maybe my understanding is flawed enough that those questions don't make sense...) --❨Ṩtruthious ℬandersnatch❩ 07:27, 28 December 2008 (UTC)

Hi, Struthious! A transmembrane protein can be said to span the membrane when it protrudes all the way through it, like in the illustration here. There are also plenty of membrane proteins that do not span their membrane: they can be inserted into a membrane but protrude from only one face of the membrane, or they can adhere to one face of the membrane and not be part of it at all (these last kinds are called peripheral membrane proteins). Does that help? – ClockworkSoul 08:00, 28 December 2008 (UTC)
Yes, that certainly helps; thank you very much! --❨Ṩtruthious ℬandersnatch❩ 01:31, 29 December 2008 (UTC)

I would like to simply find the function of transmembrane proteins. It seems too hard to find it on this page. -Anon

Merge with Integral Membrane protein and Membrane protein[edit]

I suggest to merge the 3 articles on Integral membrane protein, Membrane protein, and Transmembrane protein as they are dealing with almost the same thing. In fact, even if a "membrane protein" is not an "integral membrane protein" it would still make sense to treat these subjects under the same heading, e.g. to explain the difference. Peteruetz (talk) 03:30, 17 January 2015 (UTC)