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[edit] WikiProject class rating
This article was automatically assessed because at least one WikiProject had rated the article as start, and the rating on other projects was brought up to start class. BetacommandBot 16:32, 10 November 2007 (UTC)
[edit] Merge?
This article should NOT be merged with the tumor suppressor gene. They are NOT the same thing.
[edit] Tumor suppressive genes are recessive?
I'm wondering if this can be made a little clearer in the following way. Yes, it is true that tumor suppressor genes tend to act through a recessive mechanism in that both alleles need to be taken out to exhibit a disease. However, tumor suppressor genes overwhelmingly show a dominant pattern of inheritance. Retinoblastoma is an example. Both alleles of retinoblastoma must be mutated to show the disease. This is a recessive mechanism. However, it is listed as a dominant disease, because a child who inherits a faulty allele will almost certainly acquire a second through mutation. So when examining a pedigree of retinoblastoma or Lynch Syndrome, both of which involve mutations of tumor suppressor genes, (mismatch repair in the case of Lynch), they are dominant in transmission. Can we make that clear in this article? It is not the mechanism that determines whether or not a disease is recessive/dominant, but rather the pattern of vertical transmission, from parent to progeny. — Preceding unsigned comment added by Creightonian (talk • contribs) 01:30, 16 December 2010 (UTC)
