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I just noticed that the timeline is missing references. The 1000AD figure for Chinese variolation seems to be hard to find on the Internet, and I'm wondering where it's from. Dmutters (talk) 23:29, 26 September 2014 (UTC)
I suggest that the article should explain why a vaccine can be effective even after infection by the actual virus. Why does the actual disease agent not itself work as effectively as a vaccine. What benefit is obtained by vaccinating after infection ?188.8.131.52 (talk) 16:17, 30 October 2014 (UTC)
The article uses terms such as virus, agent, disease-causing microorganism, microbe and so on as if they are interchangeable or equivalent. Is this in fact the case. Could a clearer introcuction be written describing in less nebulous terms the range of disease causing agents that can be tackled by vaccines. If any disease might potentially be subject to a vaccine, please explain more clearly.184.108.40.206 (talk) 16:28, 30 October 2014 (UTC)