Talk:Viral evolution

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I have been wondering how to best call and introduce this article. Many of the people I work with would say they are working in the field 'virus evolution'. Therefore, I somehow think this is a better title than 'evolution of viruses' or something similar. However, it is hard to come up with a good first sentence in which the phrase 'virus evolution' appears and can be made bold. Wilke 02:57, 2 Jan 2004 (UTC)

Yep, I had the same problem, what I put there was pretty lame, I admit, but it was a start. Should this article be about the entity that is virus evolution, or an academic field "virus evolution"? Or both? --Lexor 03:11, 2 Jan 2004 (UTC)
I will think about this some more. Maybe the best strategy is to write some more contents first, and then think about what the article actually describes, and how it should be called.Wilke 03:33, 2 Jan 2004 (UTC)

I think that the co-evolution of viruses and their host should be covered together in this page. Each is constantly evolving in a "viral-host arms race". Dr d12 19:48, 8 March 2007 (UTC)

This is only true when the virus is harmful to the host (or vice-versa). If a virus is beneficial, or neutral, then the rules are different. I just want to challenge the assumption that all viruses result in reduced host fitness. Scray (talk) 03:56, 7 January 2008 (UTC)

I do agree with the proposal to move/merge the content from Intra-host evolution and Inter-host evolution to this page. Would provide better context, and the comparison between the two is key to understanding. Scray (talk) 04:01, 7 January 2008 (UTC)

I've merged these two articles into Viral evolution --Lox (t,c) 09:41, 7 January 2008 (UTC)

Suggested contents? I would suggest that if expanded this page ought to include sections on:

Viral mutation rates, fitness spectra of point mutations and substitution rates
Population dynamics and phylodynamics:
Population bottlenecks at transmission
Initial growth phase and peak viraemia
Host immune response
Selection pressures acting on viruses:
Negative / purifying (e.g. to retain basic structure, functionality and infectivity on transmission to a new host)
Positive/diversifying (e.g. HIV hypervariable regions to facillitate CTL escape)
Viral coevolution
Role of drift
Some introduction of viral recombination, especially segmented (e.g. flu) vs. nonsegmented (e.g. HIV) viruses
Host genome interactions (e.g. retroviruses)
Other host defences e.g. viral defence genes such as APOBEC family ans viral responses e.g. vif gene in HIV
A clearer account of differences between intra-host and inter-host (population level) evolution.
The viral quasispecies - and here crucially a distinction should be made between the theoretical concept itself from the mid/late 90s (more-or-less trashed now) and the current common usage of the term 'quasispecies' to mean 'a population of closely related viruses whose genetic diversity is maintained by rapid mutation but shaped predominantly by selection in response to host immune pressures'

Sorry if that list's a bit RNA-virus-centric but I don't know all that much about DNA viruses... --Comrade jo (talk) 12:14, 18 June 2009 (UTC)