On average, Tamaskan adults measure around 24-28 inches (60–70 cm) tall at the shoulder and typically weigh between 55-88 pounds (25–40 kg)–the heaviest recorded Tamaskan males (to date) weigh just under 50 kg. Females are usually slightly smaller and lighter than males, with a distinct feminine appearance. Males are more heavyset with broader heads and a heavier bone structure. Tamaskans have a lupine appearance with a straight bushy tail and thick double coat that comes in three main colors: Wolf Gray, Red Gray, and Black Gray. Each individual guard hair is agouti banded along its length. The almond-shaped eyes range from yellow through to amber and brown, with lighter colored eyes being very rare. Blue eyes are not acceptable, nor are mismatched eyes.
Overall the Tamaskan breed is healthy with only a few notable health issues, which affect a small percentage of the bloodlines to date. Roughly 10% of males suffer from cryptorchidism: undescended testes. With these cases, usually only one testicle fully descends within the scrotum, while the other testicle remains "hidden" up within the abdominal cavity. Epilepsy has been diagnosed in five dogs, affecting about 1 out of every 100 registered Tamaskan worldwide. Several dogs have been found to be carriers of degenerative myelopathy. As with all large breed dogs, hip dysplasia is a risk.
In October 2007, a Tamaskan named "Genghis Khan" featured as a wolf in a music video for the band Lucretia Choir.
In September 2010, a TDR registered male Tamaskan named "Wave" became the official Live Mascot of North Carolina State University's football team: NC State Wolfpack. Wave (aka "Tuffy") now attends most home games and can be seen stalking around the sidelines.
In September 2012, four Tamaskan Dogs were featured on the Croatian HRT 1 television program "Kućni ljubimci".