Tandy Jo Warnow is an American computer scientist, the David Bruton, Jr. Centennial Professor in Computer Science at the University of Texas at Austin. She is known for her work on the reconstruction of evolutionary trees, both in biology and in historical linguistics.
Warnow did both her undergraduate and graduate studies in mathematics at the University of California, Berkeley, earning a bachelor's degree in 1984 and a Ph.D. in 1991 under the supervision of Eugene Lawler. After postdoctoral studies at the University of Southern California from 1991-1992 and at Sandia National Laboratories in Albuquerque from 1992-1993, she took a faculty position at the University of Pennsylvania, where she remained until moving in 1999 to the University of Texas. Warnow is married to George Chacko, the Director of the Office of Planning, Analysis, and Evaluation of the Center for Scientific Review at the National Institutes of Health.
In 1995, research by Warnow, Donald Ringe, and Ann Taylor) at the University of Pennsylvania based on perfect phylogeny computations provided a comprehensive theory for the timing of the early subdivisions in the Indo-European languages. Their computations lent support to the Indo-Hittite hypothesis according to which the first of these subdivisions to separate from the rest of the Indo-European languages were the Anatolian languages. Their results also support the Graeco-Armenian hypothesis, according to which the Armenian language and Greek language form a subfamily of Indo-European. They fit the Germanic languages into the evolutionary tree of Indo-European languages, previously considered problematic, by hypothesizing that the Proto-Germanic language was closely related to the Balto-Slavic languages but then became modified by westward migrations of the Germanic tribes which led them into contact with Italic and Celtic speakers. This perfect phylogeny approach was later extended by Warnow and colleagues to allow for undetected borrowing between languages, so that language evolution is modelled with a network rather than a tree.
In 2009, Warnow and her colleagues released their SATé software for co-estimating biological multiple sequence alignments and evolutionary trees. Their software is based less strongly on firm mathematical principles than some previous co-estimation methods (such as BAli-Phy), but is significantly faster, allowing the fast construction of highly accurate trees and alignments for thousands of species. In comparison, the slow performance of previous methods limited them to only comparing dozens of species at a time.
Awards and honors
Warnow was given the David Bruton, Jr. Centennial Professorship in Computer Science in 2010. Warnow also received a John Simon Guggenheim Foundation Fellowship in 2011, a Radcliffe Institute Fellowship in 2003, a David and Lucile Packard Foundation Fellowship in 1996, and the NSF Young Investigator Award in 1994.
- Nakhleh, Luay; Ringe, Donald; Warnow, Tandy (2005), "Perfect phylogenetic networks: a new methodology for reconstructing the evolutionary history of natural languages", Language 81 (2): 382–420, JSTOR 4489897.
- Liu, Kevin; Raghavan, Sindhu; Nelesen, Serita; Linder, C. Randal; Warnow, Tandy (2009), "Rapid and accurate large-scale co-estimation of sequence alignments and phylogenetic trees", Science 324 (5934): 1561–1564, doi:10.1126/science.1171243
- Curriculum vitae, retrieved 2012-03-10.
- Tandy Jo Warnow at the Mathematics Genealogy Project
- Johnson, George (January 2, 1996), "New Family Tree Is Constructed For Indo-European", New York Times.
- Nakhleh, Ringe & Warnow 2005.
- Liu et al. 2009.
- Suchard, Marc; Redelings, Ben (2006). "BAli-Phy: simultaneous Bayesian inference of alignment and phylogeny". Bioinformatics 22: 2047–2048.
- "Method For Computing Evolutionary Trees Could Revolutionize Evolutionary Biology", ScienceDaily, June 18, 2009.
- Kloc, Joe (July 1, 2009), "How to build a better tree of life: An unconventional approach to analyzing molecular sequences allows researchers to construct larger evolutionary trees", Seed.