Tartronate-semialdehyde synthase

tartronate-semialdehyde synthase
Identifiers
EC number	4.1.1.47
CAS number	9027-24-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a tartronate-semialdehyde synthase (EC 4.1.1.47) is an enzyme that catalyzes the chemical reaction

2 glyoxylate $\rightleftharpoons$ tartronate semialdehyde + CO₂

Hence, this enzyme has one substrate, glyoxylate, and two products, tartronate semialdehyde and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is glyoxylate carboxy-lyase (dimerizing tartronate-semialdehyde-forming). Other names in common use include tartronate semialdehyde carboxylase, glyoxylate carbo-ligase, glyoxylic carbo-ligase, hydroxymalonic semialdehyde carboxylase, tartronic semialdehyde carboxylase, glyoxalate carboligase, and glyoxylate carboxy-lyase (dimerizing). This enzyme participates in glyoxylate and dicarboxylate metabolism. It has 2 cofactors: FAD, and Thiamin diphosphate.

References

• GUPTA NK, VENNESLAND B (1964). "GLYOXYLATE CARBOLIGASE OF ESCHERICHIA COLI: A FLAVOPROTEIN". J. Biol. Chem. 239: 3787–9. PMID 14257608. 
• BARKULIS SS, KRAKOW G (1956). "Conversion of glyoxylate to hydroxypyruvate by extracts of Escherichia coli". Biochim. Biophys. Acta. 21 (3): 593–4. doi:10.1016/0006-3002(56)90208-6. PMID 13363977.