His first attempts at acting were badly received, and it was to his wonderful gift of mimicry that he owed his success. His imitations, however, naturally gave offence to the important actors and managers whose peculiarities he hit off to the life. Garrick, Peg Woffington, Samuel Foote and Sheridan, after being delighted with the imitations of the others, were among the most angry, when it came to their turn, and threatened never to forgive him. Garrick never did.
As an actor, Wilkinson was most successful in Foote's plays, but his list of parts was a long one. In Shakespearian characters he was very popular in the provinces. In 1766 he became a partner of Joseph Baker in the management of several Yorkshire theatres, and married about 1768. He became sole manager after his partner's death in 1770 of a number of theatres on what was then called the Yorkshire Circuit, and he was both liberal and successful. The Theatre, Leeds, built to his order in 1771, was part of the circuit. He directed with excellent judgment and prosperity for over 30 years. His oddities were notorious, but he was a generous manager.
See his Memoirs (4 vols, 1790) and The Wandering Patentee (4 vols, 1795).
Among Wilkinson's actors were
- Miss Farren
- Julia Glover
- Dorothea Jordan (later mistress of William IV) from 1782 to 1785.
- Elizabeth Satchell
- Mrs. Siddons and the other Kembles
- Dicky Suett
- Leodis, Discovering Leeds: The Theatre Retrieved 17 December 2013
- New International Encyclopedia
- "Glover, Julia (DNB00)". Dictionary of National Biography. London: Smith, Elder & Co. 1885–1900.
- A Historical Dictionary of British Women - Cathy Hartley - Google Books. Books.google.co.uk. Retrieved 2012-11-14.
- "Siddons, Sarah (DNB00)". Dictionary of National Biography. London: Smith, Elder & Co. 1885–1900.
- "Suett, Richard". Dictionary of National Biography. London: Smith, Elder & Co. 1885–1900.
- Wm. Archer, Actors and Actresses of Great Britain and the United States, edited by Matthews and Hutton (New York, 1886)
- H. B. Baker, Our Old Actors (London, 1881)