The album is largely made up of covers of 1970s rock songs, with only a couple of original tracks thrown in: the title track "Tattoos & Tequila", written by Marti Frederiksen, which was released as the first single, and "Another Bad Day", written by Nikki Sixx, James Michael and Tracii Guns. Neil described the album has having "nothing to do with Motley Crue... Tattoos and Tequila is basically my life".
The album is a soundtrack to the book Vince released in the same year, "Tattoos & Tequila: To Hell and Back with One of Rock's Most Notorious Frontmen". Each song on the record corresponds with a chapter in the book.
As stated in an interview conducted with Nikki Sixx on Sixx Sense radio, the track, "Another Bad Day" was originally slated for Mötley Crüe, but was dropped, mainly due to the fact that drummer Tommy Lee hated the title of the song.
In 2010, Vince played "Piece of Meat" onstage with the hard rock band Scorpions.