Tazobactam

Tazobactam

Systematic (IUPAC) name
(2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	89786-04-9 Y
ATC code	J01CG02
PubChem	CID 123630
DrugBank	EXPT03012
ChemSpider	110216 Y
UNII	SE10G96M8W Y
KEGG	D00660 Y
ChEMBL	CHEMBL404 Y
Chemical data
Formula	C10H12N4O5S
Mol. mass	300.289 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C10H12N4O5S/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19/h2-3,7-8H,4-5H2,1H3,(H,16,17)/t7-,8+,10+/m1/s1 Y Key:LPQZKKCYTLCDGQ-WEDXCCLWSA-N Y
N (what is this?)  (verify)

Tazobactam is a compound that inhibits the action of bacterial beta-lactamases. It is added to the extended spectrum beta-lactam antibiotic piperacillin to produce Tazocin or Zosyn or Piprataz. It broadens the spectrum of piperacillin by making it effective against organisms that express beta-lactamase and would normally degrade piperacillin.

Tazobactam sodium is a derivative of the penicillin nucleus and is a penicillanic acid sulfone.

See also

• Sulbactam

Used with piperacillin in the treatment for Pseudomonas.

External links

• Zosyn (piperacillin / tazobactam)