Tazobactam

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Tazobactam
Tazobactam.svg
Tazobactam ball-and-stick.png
Systematic (IUPAC) name
(2S,3S,5R)-3-Methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat. B
Legal status Rx only
Routes Intravenous
Identifiers
CAS number 89786-04-9 YesY
ATC code J01CG02
PubChem CID 123630
DrugBank DB01606
ChemSpider 110216 YesY
UNII SE10G96M8W YesY
KEGG D00660 YesY
ChEMBL CHEMBL404 YesY
Chemical data
Formula C10H12N4O5S 
Mol. mass 300.289 g/mol
 YesY (what is this?)  (verify)

Tazobactam is a pharmaceutical drug that inhibits the action of bacterial β-lactamases, especially those belonging to the SHV-1 and TEM groups. It is commonly used as its sodium salt, tazobactam sodium.

Tazobactam is combined with the extended spectrum β-lactam antibiotic piperacillin in the drug piperacillin/tazobactam, one of the preferred antibiotic treatments for nosocomial pneumonia caused by Pseudomonas aeruginosa.[medical citation needed] Tazobactam broadens the spectrum of piperacillin by making it effective against organisms that express β-lactamase and would normally degrade piperacillin.[1]

Tazobactam is derived from the penicillin nucleus and is a penicillinic acid sulfone.

See also[edit]

References[edit]

  1. ^ Yang Y, Rasmussen BA, Shlaes DM (1999). "Class A beta-lactamases—enzyme-inhibitor interactions and resistance". Pharmacol Ther. 83: 141–151.