Tazobactam

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Tazobactam
Tazobactam.svg
Tazobactam ball-and-stick.png
Systematic (IUPAC) name
(2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat. B
Legal status Rx only
Routes Intravenous
Identifiers
CAS number 89786-04-9 YesY
ATC code J01CG02
PubChem CID 123630
DrugBank DB01606
ChemSpider 110216 YesY
UNII SE10G96M8W YesY
KEGG D00660 YesY
ChEMBL CHEMBL404 YesY
Chemical data
Formula C10H12N4O5S 
Mol. mass 300.289 g/mol
 YesY (what is this?)  (verify)

Tazobactam is a compound that inhibits the action of bacterial β-lactamases. It is combined with the extended spectrum β-lactam antibiotic piperacillin in the drug piperacillin/tazobactam (trade name Tazocin; also Zosyn, Piprataz). It is one of the preferred antibiotic treatments for nosocomial pneumonia caused by Pseudomonas aeruginosa. It broadens the spectrum of piperacillin by making it effective against organisms that express β-lactamase and would normally degrade piperacillin.

Tazobactam sodium is a derivative of the penicillin nucleus and is a penicillanic acid sulfone.

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