The team ceased to exist in its current structure from the end of the 2011 season as Radioshack returned their World Tour Licence to the UCI. Their two main sponsors, Radioshack and Nissan have moved their sponsorship to Team Leopard Trek. Sporting Director Johann Bruyneel moved to the newly named RadioShack-Nissan team along with several of the current Radioshack riders. While effectively a merge, there is some debate between the two teams as to the nature of the agreement. Radioshack have described it as a merge, while Flavio Becca, owner of Leopard Trek stated that his team was continuing, and simply taking over Radioshacks sponsors, and some of their riders. The new team was registered in Luxembourg with the UCI.
On November 25, 2009, The UCI ProTour Council (UPTC) announced that the team was successfully registered for the 2010 season  The team's final 2010 team roster includes 26 riders from 16 countries, after Japanese rider Fumiyuki Beppu joined in February. Demol and twelve of the riders were previously with the Kazakh team Astana in the UCI ProTour, including eight of the team's nine riders on the winning team in the 2009 Tour de France. In April 2010 Li Fuyu was suspended by the team after failing a doping test.
The team had planned on racing in the 2010 Tour de France and the 2010 Vuelta a España, among other races, but it controversially was not invited to the Vuelta. Team RadioShack went on to achieve the team victory of the 2010 Tour de France, while leading the team classification after about half its stages. It was the second time that an American team had won the team classification, preceded by Discovery Channel in 2007. After the Tour de France, the team promoted Taylor Phinney and Jesse Sergent from the Trek-Livestrong U23 team and Clinton Avery from the PWS Eijssen team to the RadioShack roster as "stagiaires" ("trainees" in French) for the remainder of the season.
While the team had 28 wins in 2011, and showed well enough to briefly be the leading team in the UCI World Tour rankings, they were nearly invisible in the Grand Tours, the races which have defined manager Johan Bruyneel's managerial career. A Tour de France besieged by crashes and injuries led to Haimar Zubeldia in 15th place being their best finisher, the worst showing for a Bruyneel-led team at the Tour in five years. The team's principal successes were the three major stage races in the United States, the Tour of California, the Tour of Utah, and the USA Pro Cycling Challenge. Team RadioShack fielded the overall winner in all three events, Chris Horner in California and Levi Leipheimer in Utah and Colorado. The team also won seven other stage races, easily the most of any major team on the season.