The song was used in numerous TV programmes and movies, perhaps most notably as the theme song of the medical television seriesHouse. The instrumental portions of the song at the beginning and the end, featuring a bass drum beat reminiscent of a heartbeat, are used in the opening theme.
"Teardrop" was first developed from a simple harpsichord riff picked out in the studio in April 1997. Vowles sent the demo to Madonna as he wanted her to record the vocals for the song (the band had previously worked with her on their 1995 reworking of the song "I Want You"). The two other band members Robert Del Naja and Grantley Marshall wanted Elizabeth Fraser of the Cocteau Twins to record the vocals, feeling her ethereal style suited the mournful melody and feel of the piece. Madonna was very keen to record the vocals, and was disappointed when the two-to-one vote went in Fraser's favour.
Fraser wrote the song's lyrics. While recording the song on May 29th, 1997, she found out that her once-close friend, Jeff Buckley had drowned. "That was so weird ... I'd got letters out and I was thinking about him. That song's kind of about him – that's how it feels to me anyway."
The 12" release contains the same songs but in a different order. The cassette release contains an edited version of the original song, as well as the Scream Team remix and the B-side "Euro Zero Zero", but is missing the remix by Mad Professor.
José González covered "Teardrop" for his second album In Our Nature. The single was released across Europe on 12 November 2007. The single features the non-album instrumental B-side "Four Forks Ache." This version was also featured in the medical drama House M.D. in the episode "Wilson's Heart".