Technetium (99mTc) exametazime

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Technetium (99mTc) exametazime
Tc-99m exametazime skeletal.svg
Systematic (IUPAC) name
[[(3RS,3'RS)-3,3'-[(2,2-Dimethyltrimethylene)diimino][di-2-butanone]dioximato](3-)-N,N',N'',N''']oxotechnetium (99mTc)
Clinical data
Licence data US FDA:link
Pregnancy cat. C (US)
Legal status -only (US)
Routes Intravenous
Identifiers
CAS number
100551-63-1 (exametazime)
ATC code V09AA01
V09HA02 (labelled leucocytes)
PubChem CID 9552069
UNII 3B744AG22N YesY
Chemical data
Formula C13H25N4O3Tc 
Mol. mass 384.3655 g/mol
 YesY (what is this?)  (verify)

Technetium (99mTc) exametazime is a radiopharmaceutical sold under the trade name Ceretec, and is used for the detection of altered regional cerebral perfusion in stroke[1] and other cerebrovascular diseases. It can also be used for the labelling of leukocytes to localise intra-abdominal infections[2] and inflammatory bowel disease.[3] Exametazime (the part without technetium) is sometimes referred to by its chemical name of hexamethylpropyleneamine oxime or HMPAO.

Chemistry[edit]

Exametazime (hexamethylpropyleneamine oxime, HMPAO)

The drug consists of two of the three stereoisomers of hexametazime (HMPAO), one of which is shown here, the other being its enantiomer.[4] The third stereoisomer is the meso form. Exametazime acts as a chelating agent for the radioisotope technetium-99m.

References[edit]

  1. ^ Moretti, J. L.; Defer, G.; Cinotti, L.; Cesaro, P.; Degos, J. D.; Vigneron, N.; Ducassou, D.; Holman, B. L. (1990). ""Luxury perfusion" with 99mTc-HMPAO and 123I-IMP SPECT imaging during the subacute phase of stroke". European journal of nuclear medicine 16 (1): 17–22. doi:10.1007/BF01566007. PMID 2307169.  edit
  2. ^ Weldon, M. J.; Joseph, A. E.; French, A.; Saverymuttu, S. H.; Maxwell, J. D. (1995). "Comparison of 99m technetium hexamethylpropylene-amine oxime labelled leucocyte with 111-indium tropolonate labelled granulocyte scanning and ultrasound in the diagnosis of intra-abdominal abscess". Gut 37 (4): 557–564. doi:10.1136/gut.37.4.557. PMC 1382910. PMID 7489945.  edit
  3. ^ Ui, K.; Yamaguchi, T. (1991). "Therapy and diagnosis of emergency shock patients". Nihon Naika Gakkai zasshi. the Journal of the Japanese Society of Internal Medicine 80 (12): 1892–1896. PMID 1804909.  edit
  4. ^ Monography in the European Pharmacopoeia

External links[edit]