Sperling has been the musical director, conductor, stage director and/or arranger for such Broadway musicals as the revival of South Pacific (2008) and The Light in the Piazza (2005), and for some ten Off-Broadway musicals, starting with Gus and Al in 1989 through Striking 12 in 2006. He appeared on-stage in the musical Titanic (1997) as a performer and one of the on-stage trio of musicians. He began stage directing in regional theatre in 2001, and then directed the musical See What I Wanna See, both regionally and off-Broadway, in 2004 and 2005.
He is the musical conductor for concerts for performer Victoria Clark. The two met at Yale University, when they sang in the Yale Chapel Choir and he was also the first violist in the Yale Symphony Orchestra. He has also conducted concerts for Audra McDonald, such as her Houston Grand Opera debut in March 2006  and her New York Philharmonic New Year's Eve concert, December 31, 2006.