Tegafur

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Tegafur
Systematic (IUPAC) name
(RS)-5-fluoro-1-(tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status Prescription only
Routes Oral
Identifiers
CAS number 17902-23-7 YesY
ATC code L01BC03
PubChem CID 288216
ChemSpider 254191 YesY
UNII 1548R74NSZ YesY
KEGG D01244 YesY
ChEMBL CHEMBL20883 N
Synonyms 5-fluoro-1-(oxolan-2-yl)pyrimidine-2,4-dione
Chemical data
Formula C8H9FN2O3 
Mol. mass 200.16 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Tegafur (INN) is a chemotherapeutic fluorouracil prodrug used in the treatment of cancers. It is a component of the combination drug tegafur-uracil. When metabolized, it becomes 5-fluorouracil.[1]

[edit] References

  1. ^ El Sayed, YM; Sadée, W (1983). "Metabolic activation of R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) to 5-fluorouracil by soluble enzymes". Cancer research 43 (9): 4039–44. PMID 6409396. 


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