Tegafur

Tegafur
Systematic (IUPAC) name
	(RS)-5-fluoro-1-(tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Oral
Identifiers
CAS number	17902-23-7
ATC code	L01BC03
PubChem	CID 288216
ChemSpider	254191
UNII	1548R74NSZ
KEGG	D01244
ChEMBL	CHEMBL20883
Synonyms	5-fluoro-1-(oxolan-2-yl)pyrimidine-2,4-dione
Chemical data
Formula	C8H9FN2O3
Mol. mass	200.16 g/mol
SMILES	eMolecules & PubChem
	InChI InChI=1S/C8H9FN2O3/c9-5-4-11(6-2-1-3-14-6)8(13)10-7(5)12/h4,6H,1-3H2,(H,10,12,13)/t6-/m1/s1 ; Key:WFWLQNSHRPWKFK-ZCFIWIBFSA-N ;
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Tegafur (INN) is a chemotherapeutic fluorouracil prodrug used in the treatment of cancers. It is a component of the combination drug tegafur-uracil. When metabolized, it becomes 5-fluorouracil.^[1]

[edit] References

^ El Sayed, YM; Sadée, W (1983). "Metabolic activation of R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) to 5-fluorouracil by soluble enzymes". Cancer research 43 (9): 4039–44. PMID 6409396.

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