Template:PBB/3630

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Insulin
InsulinHexamer.jpg
High-resolution model of six insulin molecules assembled in a hexamer, highlighting the threefold symmetry, the zinc ion holding it together (pink sphere), and the histidine residues (pink sticks) involved in zinc binding. Inactive insulin is stored in the body as a hexamer, while the active form is the monomer. [1]
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols INS ; IDDM2; ILPR; IRDN; MODY10
External IDs OMIM176730 MGI96573 HomoloGene173 ChEMBL: 5881 GeneCards: INS Gene
RNA expression pattern
PBB GE INS 206598 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3630 16334
Ensembl ENSG00000254647 ENSMUSG00000000215
UniProt P01308 P01326
RefSeq (mRNA) NM_000207 NM_001185083
RefSeq (protein) NP_000198 NP_001172012
Location (UCSC) Chr 11:
2.18 – 2.18 Mb
Chr 7:
142.68 – 142.7 Mb
PubMed search [1] [2]

References

These references will appear in the article, but this list appears only on this page.
  1. ^ PDB 1ai0; Chang X, Jorgensen AM, Bardrum P, Led JJ (1997). "Solution structures of the R6 human insulin hexamer,". Biochemistry 36 (31): 9409–22. doi:10.1021/bi9631069. PMID 9235985.