Tenascin-R

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Tenascin R
Protein TNR PDB 1tdq.png
PDB rendering based on 1tdq.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols TNR ; TN-R
External IDs OMIM601995 MGI99516 HomoloGene124416 GeneCards: TNR Gene
RNA expression pattern
PBB GE TNR 206990 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7143 21960
Ensembl ENSG00000116147 ENSMUSG00000015829
UniProt Q92752 Q8BYI9
RefSeq (mRNA) NM_003285 NM_022312
RefSeq (protein) NP_003276 NP_071707
Location (UCSC) Chr 1:
175.29 – 175.71 Mb
Chr 1:
159.74 – 159.92 Mb
PubMed search [1] [2]

Tenascin-R is a protein that in humans is encoded by the TNR gene.[1][2][3]

Function[edit]

Tenascin-R (TNR) is an extracellular matrix protein expressed primarily in the central nervous system. It is a member of the tenascin (TN) gene family, which includes at least 3 genes in mammals: TNC (or hexabrachion), TNX (TNXB), and TNR.[4] The genes are expressed in distinct tissues at different times during embryonic development and are present in adult tissues.[supplied by OMIM][3]

References[edit]

  1. ^ Carnemolla B, Leprini A, Borsi L, Querze G, Urbini S, Zardi L (Jun 1996). "Human tenascin-R. Complete primary structure, pre-mRNA alternative splicing and gene localization on chromosome 1q23-q24". J Biol Chem 271 (14): 8157–60. doi:10.1074/jbc.271.14.8157. PMID 8626505. 
  2. ^ Leprini A, Gherzi R, Siri A, Querze G, Viti F, Zardi L (Jan 1997). "The human tenascin-R gene". J Biol Chem 271 (49): 31251–4. doi:10.1074/jbc.271.49.31251. PMID 8940128. 
  3. ^ a b "Entrez Gene: TNR tenascin R (restrictin, janusin)". 
  4. ^ Erickson HP (October 1993). "Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions". Curr. Opin. Cell Biol. 5 (5): 869–76. doi:10.1016/0955-0674(93)90037-Q. PMID 7694605. 

Further reading[edit]