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Tenascin R
Protein TNR PDB 1tdq.png
PDB rendering based on 1tdq.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TNR ; TN-R
External IDs OMIM601995 MGI99516 HomoloGene124416 GeneCards: TNR Gene
RNA expression pattern
PBB GE TNR 206990 at tn.png
More reference expression data
Species Human Mouse
Entrez 7143 21960
Ensembl ENSG00000116147 ENSMUSG00000015829
UniProt Q92752 Q8BYI9
RefSeq (mRNA) NM_003285 NM_022312
RefSeq (protein) NP_003276 NP_071707
Location (UCSC) Chr 1:
175.29 – 175.71 Mb
Chr 1:
159.74 – 159.92 Mb
PubMed search [1] [2]

Tenascin-R is a protein that in humans is encoded by the TNR gene.[1][2][3]


Tenascin-R (TNR) is an extracellular matrix protein expressed primarily in the central nervous system. It is a member of the tenascin (TN) gene family, which includes at least 3 genes in mammals: TNC (or hexabrachion), TNX (TNXB), and TNR.[4] The genes are expressed in distinct tissues at different times during embryonic development and are present in adult tissues.[supplied by OMIM][3]


  1. ^ Carnemolla B, Leprini A, Borsi L, Querze G, Urbini S, Zardi L (Jun 1996). "Human tenascin-R. Complete primary structure, pre-mRNA alternative splicing and gene localization on chromosome 1q23-q24". J Biol Chem 271 (14): 8157–60. doi:10.1074/jbc.271.14.8157. PMID 8626505. 
  2. ^ Leprini A, Gherzi R, Siri A, Querze G, Viti F, Zardi L (Jan 1997). "The human tenascin-R gene". J Biol Chem 271 (49): 31251–4. doi:10.1074/jbc.271.49.31251. PMID 8940128. 
  3. ^ a b "Entrez Gene: TNR tenascin R (restrictin, janusin)". 
  4. ^ Erickson HP (October 1993). "Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions". Curr. Opin. Cell Biol. 5 (5): 869–76. doi:10.1016/0955-0674(93)90037-Q. PMID 7694605. 

Further reading[edit]