Terlipressin
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AHFS/Drugs.com | International Drug Names |
Routes of administration | IV |
ATC code | |
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Pharmacokinetic data | |
Protein binding | ~30% |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.035.149 |
Chemical and physical data | |
Formula | C52H74N16O15S2 |
Molar mass | 1227.37 g/mol g·mol−1 |
3D model (JSmol) | |
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Terlipressin (trade names Teripress by New Medicon Pharma and Glypressin by Ferring Pharmaceuticals) is an analogue of vasopressin used as a vasoactive drug in the management of low blood pressure. It has been found to be effective when norepinephrine does not help.
Indications for use include norepinephrine-resistant septic shock[2] and hepatorenal syndrome.[3] In addition, it is used to treat bleeding esophageal varices.[4]
Availability
Terlipressin is currently not available in the United States,[5] or Canada,[6] but it is available in New Zealand,[7] Australia, much of Europe,[8] India & UAE.
Contraindications
Terlipressin must not be used during pregnancy.
See also
References
- ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
- ^ O'Brien A, Clapp L, Singer M (2002). "Terlipressin for norepinephrine-resistant septic shock". Lancet. 359 (9313): 1209–10. doi:10.1016/S0140-6736(02)08225-9. PMID 11955542.
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: CS1 maint: multiple names: authors list (link) - ^ Uriz J, Ginès P, Cárdenas A, Sort P, Jiménez W, Salmerón J, Bataller R, Mas A, Navasa M, Arroyo V, Rodés J (2000). "Terlipressin plus albumin infusion: an effective and safe therapy of hepatorenal syndrome". J Hepatol. 33 (1): 43–8. doi:10.1016/S0168-8278(00)80158-0. PMID 10905585.
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: CS1 maint: multiple names: authors list (link) - ^ Ioannou G, Doust J, Rockey D (2003). Ioannou, George N (ed.). "Terlipressin for acute esophageal variceal hemorrhage". Cochrane Database Syst Rev (1): CD002147. doi:10.1002/14651858.CD002147. PMID 12535432.
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: CS1 maint: multiple names: authors list (link) - ^ "{1} And {2} Report Fast Track Designation For Terlipressin In Type 1 Hepatorenal Syndrome - News, Search Jobs, Events".
- ^ "Drug Product Search".
- ^ http://www.medsafe.govt.nz/profs/datasheet/g/Glypressin01mgmlFerringinj.pdf
- ^ http://www.drugs.com/international/terlipressin.html