Terodiline

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Terodiline
Terodiline.png
Systematic (IUPAC) name
N-tert-butyl-4,4-di(phenyl)butan-2-amine
Clinical data
Legal status ?
Identifiers
CAS number  YesY
ATC code G04BD05
PubChem CID 23480
ChemSpider 21952 YesY
UNII 70KG06964W YesY
ChEMBL CHEMBL363295 YesY
Chemical data
Formula C20H27N 
Mol. mass 281.435 g/mol
 YesY (what is this?)  (verify)

Terodiline is a drug used in urology as an antispasmodic.

It relaxes the smooth muscle and used to reduce bladder tone in treatment of urinary frequency and incontinence. Muscle relaxation caused by terodiline, is probably due to its anticholinergic and calcium antagonist activity.

However, it also blocks IKr (Kv11.1) channels (see hERG gene) so can pose a risk for torsades de pointes. This cardiotoxicity is concentration dependent.[1]

References[edit]

  1. ^ Thomas SH, Higham PD, Hartigan-Go K, Kamali F, Wood P, Campbell RW, Ford GA. "Concentration dependent cardiotoxicity of terodiline in patients treated for urinary incontinence".