A right-handed batter and thrower, Moore began his professional baseball career in 1932. In 1934, he hit .328 in the American Association and earned a roster spot with the Cardinals the following season.
When his playing days ended, Moore served two terms (1949–52; 1956–58) as a Cardinals coach. He also managed the Philadelphia Phillies in 1954. After beginning the 1954 season as a Phillies scout, he replaced Steve O'Neill as the club's manager on July 15. He managed the Phils for exactly half a season — 77 games — and the team won 35 of those games (for a winning percentage of .455).