Testosterone undecanoate
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| Systematic (IUPAC) name | |
| [(8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl] undecanoate | |
| Clinical data | |
| Pregnancy cat. | X (USA), Teratogenic effects |
| Legal status | Schedule III (USA) Schedule IV (Canada) |
| Routes | oral,I.V |
| Pharmacokinetic data | |
| Bioavailability | 7% |
| Metabolism | Liver, Testis and Prostate |
| Half-life | 1-12 days |
| Excretion | Urine |
| Identifiers | |
| CAS number | 5949-44-0 |
| ATC code | G03BA03 |
| PubChem | CID 65157 |
| ChemSpider | 23089522  |
| KEGG | D06087 |
| Chemical data | |
| Formula | C30H48O3 |
| Mol. mass | 456.70032 |
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Testosterone undecanoate or testosterone undecylate is an ester of testosterone which is used for the treatment of male hypogonadism, and is currently under research for use as a male contraceptive. It is sold and distributed under the brand names Andriol, Undestor, Nebido, Pantestone, Restandol, Cernos Depot and Nebido-R and Reandron 1000.[1]
Andriol is a version of the anabolic steroid testosterone undecanoate developed by the pharmaceutical company Organon. This testosterone preparation is encapsulated and sealed in an oil base in a 40 mg capsule taken orally. According to Organon, this method bypasses the liver, preventing it from being damaged by the liver and from adding damaging stresses to the liver found in other testosterone preparations. It is said to enter the body as a fat through the lymphatic system. Experience from users indicates that in doses of less than 240 mg per day, effects are negligible, except at the very onset of use, while even in higher doses, effects are still minimal. It is therefore thought that most of the steroid is somehow not making it into the blood stream.[2]
[edit] References
- ^ Köhn, FM; Schill, WB (Nov 2003). "A new oral testosterone undecanoate formulation.". World J Urol 21 (5): 311–5. doi:10.1007/s00345-003-0372-x. PMID 14579074.
- ^ http://www.mesomorphosis.com/steroid-profiles/andriol.htm, http://www.steroidology.com/andriol-testosterone-undecanoate/, http://www.testosteroneundecanoate.com/, http://www.medicinenet.com/testosterone_undecanoate-oral_capsule/article.htm
[edit] External links
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