|Jmol-3D images||Image 1|
|Molar mass||445.43 g/mol|
| (what is: / ?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Tetrahydrofolic acid, or tetrahydrofolate, is a folic acid derivative.
Human synthesis 
Bacterial synthesis 
Many bacteria use dihydropteroate synthetase to produce dihydropteroate in bacteria, a molecule without function in humans. This makes it a useful target for sulfonamide antibiotics, which compete with the PABA precursor.
It is a coenzyme in many reactions, especially in the metabolism of amino acids and nucleic acids. It acts as a donor of a group with one carbon atom. It gets this carbon atom by sequestering formaldehyde produced in other processes. A shortage in THF can cause megaloblastic anemia.
Methotrexate acts on dihydrofolate reductase, like pyrimethamine or trimethoprim, as an inhibitor and thus reduces the amount of tetrahydrofolate made. This may result in megaloblastic anemia.
Tetrahydrofolic acid is involved in the conversion of formiminoglutamic acid to glutamic acid; this may reduce the amount of histidine available for decarboxylation and protein synthesis, and hence the urinary histamine and formiminoglutamic acid may be decreased.