State Highway 354 or SH 354 is a state highway in the Texas Panhandle. This route is a replacement of a portion of SH 5, which was replaced by U.S. Routes in 1944. This section was bypassed, and was renumbered to keep state highway status.
SH 354 begins at an intersection with US 385 in the town of Channing. The highway is known as 7th Street in Channing and the road extends to the west of the US 385 intersection as FM 767. SH 354 heads to the east from this intersection through Hartley County. It passes over into Moore County before an intersection with FM 2202. The highway continues east to its eastern terminus at an intersection with a concurrentUS 87 and US 287. The road continues east past this intersection as FM 1913.