Loop 279 begins at an interchange with I-40 Business and Bell Street near Amarillo College in Amarillo, Potter County, heading east on SW 9th Avenue, a four-lane divided highway. The road soon becomes a five-lane road with a center left-turn lane as it passes through commercial areas before heading between the Amarillo Country Club to the north and residential areas to the south, losing the center turn lane. The highway turns northeast onto Bushland Boulevard at this point and continues south of the golf course. Loop 279 narrows into a two-lane road and heads past businesses, turning east onto SW 6th Avenue. The road heads through more commercial areas with some homes before heading into an area of more businesses. The highway heads into the commercial downtown of Amarillo, widening into a four-lane road. Here, Loop 279 crosses the southbound direction of US 287 before ending at an intersection with the northbound direction of US 87.
The route was originally the main line of U.S. Route 66, which turned north on Fillmore Street (concurrent with US 87) to the current Business IH 40. A new alignment along Amarillo Boulevard was built ca. 1953, and in mid-1954 the old alignment (west of Fillmore Street) was designated Loop 279 and signed as Business US 66 (Business US 66 continued north on Fillmore Street to new US 66). At some point, Fillmore Street became one-way northbound, and westbound Business US 66 was moved to either Taylor Street or Pierce Street. When US 66 was decommissioned in Texas in 1985, the Business US 66 designation was dropped.