Spur 261 begins at an interchange with I-610 in Houston, Harris County, at which point it heads north on a one-way pair following three-lane North Shepherd Drive northbound and three-lane North Durham Drive southbound. The one-way pair heads through commercial areas, with the southbound direction joining the northbound direction on six-lane divided North Shepherd Drive. The road runs past more businesses, crossing under a BNSF Railway line. The highway continues between residential neighborhoods to the west and commercial areas to the east before crossing West 43rd Street/West Crosstimbers Road, at which point it is lined with more businesses. The road continues through more commercial areas, with the median widening slightly. Spur 261 reaches its northern terminus at an interchange with I-45.