In 1976, Spur 527 was designated as a spur of US 59 in Houston. The freeway was the original routing of US 59 into downtown before being rerouted further east. The freeway was built in the early 1960s as the overpasses at Richmond Avenue and Alabama Street had been completed by 1961.
Spur 527 branches off US 59 on the west side of Midtown and heads northeast, feeding traffic into downtown. It provides access to Richmond Avenue and Travis Street before curving towards the north as it passes over Alabama Street. As it continues north through Midtown, the spur provides access to Louisiana Street before coming to an end at Elgin Street. The northbound lanes continue onto Brazos Street past Elgin Street and Bagby Street becomes the southbound lanes of Spur 527 after crossing Elgin Street.