The first section of the book is about her family and upbringing. Silverman writes about her growing up wetting her bed until age 16. At age 2, she would make her father laugh by saying "fuck". Her family did not find her sense of humor offensive, and supported her style of comedy. She says that Garry Shandling is her heaviest influence, and how, like him, she has created a semi-fictional public persona of herself. She admits to avidly smoking marijuana. The book's (fictional) afterword is by God, writing about Silverman in the year 2063, on the occasion of her death at 93, with the eipitaph "She loved dogs, New York, television, children, friendship, sex, laughing, heartbreaking songs, marijuana, farts, and cuddling." 
HarperCollins purchased the rights to publish a Silverman memoir in 2008 for $2.5 million. The book was released on April 20, which, as "4/20", is a day of celebration for marijuana users. Silverman produced a promotional letter exclusively for Amazon.com, wherein she compares herself ironically to Ernest Hemingway and Fyodor Dostoevsky, classing herself as a serious writer.
The book was reviewed favorably by Vanity Fair, Publishers Weekly, the New York Times, the Los Angeles Times and People. New York wrote that Silverman, in her book, seems to be saying "Obviously I’m joking, but it’s also me up there [on stage]". The audiobook was nominated for a Grammy Award.
- Sarah Silverman: Idiot Savant | Talking Writing
- "Animal Magnetism: You May Never Understand Sarah Silverman, But Her New Memoir, The Bedwetter, Explains a Lot", Will Leitch, New York Books, Apr 11, 2010
- "Three HarperCollins Imprints Face Off For $2.5 Million Sarah Silverman Book", Leon Neyfakh, New York Observer, November 13, 2008
- Amazon.com: The Bedwetter: Stories of Courage, Redemption, and Pee (9780061856457): Sarah Silverman: Books