Descent from the Cross is a 1634 painting by Rembrandt, now in the Hermitage Museum.
By 1693 it was owned by Valerius Röver senior of Delft. It remained in the Netherlands until 1750, when it was bought by William VIII, Landgrave of Hesse-Kassel. It remained in his family's collection until it was confiscated by the French in 1806 and allocated to the empress Joséphine de Beauharnais's collection at Château de Malmaison. It was then bought in 1814 by Alexander I of Russia after the fall of Napoleon and placed in the Hermitage, where it remains.