The Greatest Hits of Eric Burdon and The Animals was the group's compilation representing The Animals' last three lineups, and showcased their venture into psychedelic rock. It was released in March 1969 in the US but never put out in the United Kingdom; it was the last album MGM Records would release in (more or less) the group's lifetime. Despite containing three tracks that had been US Top 15 singles, the collection was not commercially successful, placing only at number 153 on the Billboard 200.
The 1979 Rolling Stone Record Guide said the album's songs "are, in a way, great fun as memorabilia, they are surely no more than that."Allmusic considers it "An okay compilation of its kind", but supplanted by later compilations issued after the group had broken up.