The series was created by Dannah Phirman and Danielle Schneider. Paul Scheer and Jonathan Stern serve as executive producers. It is part of Hulu's initiative to produce original scripted programming. The show is a scripted parody of the reality television franchise The Real Housewives on Bravo. The series depicts the purportedly exclusive and glamorous world of six "hot housewives" in Orlando, Florida. The show follows the women as they fight over everything except for their love of shoes, plastic surgery, and the pursuit of spending all of their husbands' money.
Casey Wilson as Tawny St. John: "The Trophy Wife" – The self-obsessed, gold digging trophy hotwife who's cheating on her much older husband Phil with her fitness trainer, Heath. She defends her actions by claiming that Phil is dying, when he in fact just has allergies. She seemingly has no real marketable skills other than attending charity events, partying, and making music videos. Though she has recently attempted to release her own cosmetic products such as her new line of "eyebrow extensions", and also runs a charity called "Classy Canines", which supplies high heels for dogs.
Danielle Schneider as Shauna Maducci: "The Bankrupt Overspender" – The brassy Italian-American hotwife with anger control problems. She is addicted to shopping and is constantly fighting with everyone from her husband Anthony to her "best friend" Tawny. She and her husband are on the verge of bankruptcy, which she is single-handedly responsible for because of her overspending habits.
Tymberlee Hill as Phenomenon "Phe Phe" Reed: "The Entrepreneur" – The flashy African-American hotwife known for "speaking her mind" and referring to herself in the third person and coining catchphrases involving her name such as "I'm just bein' Phe Phe!". Her "entrepreneurial" pursuits include: lawyer, foot model, aspiring taxidermist, among other careers.
Andrea Savage as Veronica Von Vandervon: "The Cougar" – A wealthy and classy woman who is known for her vulgar sense of humor and is always on the prowl for younger men. She often insists on explaining her overly suggestive jokes. She speaks in an English accent, although she later states in the reunion special that she never said she was British, she only sounds British because she is white and rich. The sex-obsessed Veronica is an independent businesswoman and the heiress to the "Hot Holes, Heavy Putting" mini-golf fortune.
Angela Kinsey as Crystal Simmons: "The Religious Zealot" – A devout Christian and local Orlando weather girl. Though she claims to not have actually read the Bible because “it’s written in Jewish.” She is known for her "holier than thou" attitude and being judgmental of everyone, especially of her younger sister Amanda.
Kristen Schaal as Amanda Simmons: "The Drug Addled Former Child Star" – Crystal's younger sister and a former child star who made her claim-to-fame as the "Florida Prune Juice girl" in a number of commercials as a child. She claims her substance abuse issues are behind her. She is not technically a wife as she is chronically single, but has hopes being on the show will help her regain her fame.
Paul Scheer as Matty Green – The show's executive producer who appears in every episode to plug his after-show "The Hotwives Cooldown".
Joey McIntyre as Heath – Tawny's fitness trainer with whom she's having an affair while her husband is on his deathbed.
Stephen Tobolowsky as Phil – Tawny's much older, wealthy husband, who she thinks is dying, or she hopes is dying anyway. He is completely oblivious to the fact that Tawny is having an affair with Heath.
Matt Besser as Anthony – Shauna's husband. He and Shauna are constantly fighting and both appear to hate each other.
Jerry Minor as Rodney – Phe Phe's constantly cheating husband. He works as a sports mascot. He and Phe Phe later get divorced after she caught him in bed with another woman.
Seth Morris as T.J. – Crystal's very controlling husband, who forbids Crystal from most activities because it goes against the Bible, which she has not read because he claims it is in "Jewish".
Dannah Phirman as Alli – A wannabe hotwife who is often seen hanging around the ladies, usually trying to spread gossip. She isn't a hotwife but likes to tell everyone she could be.
Sterling Knight as Billy – Veronica's under-aged boyfriend. It was shown he was not very smart.
Jeff Hiller as Antoine – The party planner often hired by the ladies.