The Medical Letter on Drugs and Therapeutics
|The Medical Letter on Drugs and Therapeutics|
|Abbreviated title (ISO 4)||Med. Lett. Drugs Ther.|
|Language||English, French, Italian, Japanese, Spanish|
|Publisher||The Medical Letter, Inc. (United States)|
The Medical Letter on Drugs and Therapeutics (commonly referred to as The Medical Letter) is a scientific journal providing evaluations of drugs. It has a print and electronic circulation of well over 450,000 subscribers in 125 countries worldwide.
It is published biweekly (26 issues/year) in several languages: English (US and Canadian editions), French (Canadian and European editions), Italian, Japanese, and Spanish.
Editorial process 
Articles for The Medical Letter are drafted by either an editor or external consultant using both published and available unpublished studies that are reviewed for methodological rigor with special attention to the results of clinical trials. A preliminary draft is circulated to every member of the advisory board and 10-20 other investigators with relevant clinical or experimental experience with the article's topic. Drafts are also provided to the Food and Drug Administration (FDA) and Centers for Disease Control and Prevention (CDC) and to all first authors of articles cited in the text. The evaluation of each drug includes a discussion of its efficacy, side effects, and a comparison with older, more established agents. The final version of the paper includes comments from the reviewers and is checked and edited for accuracy and readability.