The Seeds released two singles before the album was released in 1966: "Can't Seem to Make You Mine" in June 1965 and "Pushin' Too Hard" in November.The Seeds was released in April 1966 and charted in the United States, peaking at No. 132 on the Billboard Top LPs & Tapes chart. The first single to follow up the album's release was "Try to Understand", which failed to chart in the United States. "Pushin' Too Hard" was re-issued in October 1966 and charted in 1967 in the United States, peaking at No. 36 in February.
The Seeds has been re-issued several times in the United Kingdom on vinyl and CD. Several re-issues contain bonus tracks while the album itself has also been re-released as a double album on compact disc with The Seeds's second album, A Web of Sound. Some of the re-issues omit the song "Lose Your Mind" from the original album vinyl release.
In 2012, Big Beat Records re-released The Seeds' debut album as a deluxe edition, with the album in remastered mono form, plus ten new bonus tracks of previously unreleased material.
Modern reception of the album has been generally positive. In their review for the double disc re-issue, Allmusic gave the album a positive rating of four stars out of five, writing "The Seeds is probably the best album by any of the original American garage bands, without the usual time-filling cover versions and elongated jams, and of course it features the immortal "Pushin' Too Hard" and the even better "Can't Seem to Make You Mine," two classics of the Nuggets era." The British music magazine Uncut gave the compilation a positive rating of four and half stars out of five, describing the album as "...A brilliantly simple, headlong surge of fuzz-drenched guitar, bubbling organ riffs and Saxon's raw, throat-tearing vocals..."