The Southern Harmony and Musical Companion is the second album by the American blues rock group The Black Crowes, released on May 12, 1992. It was the first record by the band to feature Marc Ford on lead guitar, replacing Jeff Cease, who was fired the year before. The album's name derives from the full name of the Southern Harmony, an influential 1835 hymnal compiled by William Walker.
It features four hit singles; "Remedy" (#1 on the Album Rock Tracks chart for 11 weeks), "Thorn in My Pride" (#1 on the Album Rock Tracks chart for four weeks), "Sting Me" (#1 on the Album Rock Tracks chart for two weeks), and "Hotel Illness" (#1 on the Album Rock Tracks chart for six weeks). It was a record for an album to feature four album rock number-one hits (previously set by Tom Petty in 1989, with three). The album itself reached the top spot of the Billboard 200 album chart, propelled by the success of these singles.