Thirty years have passed since Alexandra Medford, Jane Spofford and Sukie Ridgemont terrorized the Rhode Island town of Eastwick with their witchcraft and cavorted with Darryl Van Horne, possibly the devil. All three women had remarried, left Eastwick and gradually fallen out of touch. They begin to restore their friendship as they one by one become widowed. After touring the Canadian Rockies (Alexandra), Egypt (Alexandra and Jane) and China (all three), they agree to revisit Eastwick, largely out of unspoken guilt for their role in the death of their romantic rival, Jenny Gabriel, who died of metastasizedovarian cancer shortly after her marriage to Van Horne. While conducting a white magic spell at their rented condominium (part of Van Horne's old mansion), Jane, who had earlier been complaining of odd electric shocks, suddenly dies of an aneurysm of the aorta. Alexandra and Sukie both learn that Jenny's brother, Christopher (who had also been Van Horne's lover) killed Jane using methods involving electrons and quantum physics he learned from Van Horne. He plans to kill the other two witches next but doesn't, possibly because Sukie seduces him. Alexandra returns to New Mexico, where she previously settled with her second husband after first leaving Eastwick, and Sukie moves to Manhattan with Christopher.