Thermic effect of food
Thermic effect of food, or TEF in shorthand, is the amount of energy expenditure above the resting metabolic rate due to the cost of processing food for use and storage. It is one of the components of metabolism along with resting metabolic rate and the exercise component. Two other terms commonly used to describe the thermic effect of food are dietary induced thermogenesis (DIT) and specific dynamic action (SDA). A commonly-used estimate of the thermic effect of food is about 10% of one's caloric intake, though the effect varies substantially for different food components. For example, dietary fat is very easy to process and has very little thermic effect, while protein is hard to process and has a much larger thermic effect.
Factors that affect the thermic effect of food 
The thermic effect of food is increased by both aerobic training of sufficient duration and intensity and by anaerobic weight training. However, the increase is marginal, amounting to 7-8 cal per hour. The primary determinants of daily TEF are the quantity and composition of the food ingested.
Although some believe that TEF is reduced in obesity, discrepant results and inconsistent research methods have failed to validate such claims.
Types of foods 
The thermic effect of food is the energy required for digestion, absorption, and disposal of ingested nutrients. Its magnitude depends on the composition of the food consumed:
- Carbohydrates: 5 to 15 % of the energy consumed
- Protein: 20 to 35%
- Fats: at most 5 to 15 %
Raw celery and grapefruit are often claimed to have negative caloric balance (requiring more energy to digest than recovered from the food), presumably because the thermic effect is greater than the caloric content due to the high fibre matrix that must be unraveled to access their carbohydrates. However, there has been no research carried out to test this hypothesis and a significant amount of the thermic effect depends on the insulin sensitivity of the individual, with more insulin-sensitive individuals having a significant effect while individuals with increasing resistance have negligible to zero effects.
The Functional Food Centre at Oxford Brookes University conducted a study into the effects of chilli and medium-chain triglycerides (MCT) on Diet Induced Thermogenesis (DIT). They concluded that "adding chilli and MCT to meals increases DIT by over 50 % which over time may accumulate to help induce weight loss and prevent weight gain or regain".
Australia's Human Nutrition conducted a study on the effect of meal content in lean women's diets on the thermic effect of food and found that the inclusion of an ingredient containing increased soluble fibre and amylose did not reduce spontaneous food intake but rather was associated with higher subsequent energy intakes despite its reduced glycaemic and insulinemic effects.
Measuring TEF 
The thermic effect of food should be measured for greater than or equal to five hours.
The American Journal of Clinical Nutrition published that TEF lasts beyond 6 hours for the majority of people.
Processed foods and TEF 
Research has found that the thermic effect of food contributes to the fact that calories may not all be equal in terms of weight gain. Sadie Barr showed that the consumption of processed foods led to a 50% decrease in postprandial energy expenditure.
- Denzer, CM; JC Young (2003 September). "The effect of resistance exercise on the thermic effect of food.". International Journal of Sport Nutrition and Exercise Metabolism 13 (3): 396–402. PMID 14669938. Retrieved 2010-08-10.
- Christensen, Peter. "What is the thermic effect of food?". Retrieved March 28, 2005.
- Granata, G. P.; Brandon, L. J. (2002). "The Thermic Effect of Food and Obesity: Discrepant Results and Methodological Variations". Nutrition Reviews 60 (8): 223–233. doi:10.1301/002966402320289359. PMID 12199298.
- Segal, K. R.; Albu, J.; Chun, A.; Edano, A.; Legaspi, B.; Pi-Sunyer, F. X. (1992). "Independent effects of obesity and insulin resistance on postprandial thermogenesis in men". Journal of Clinical Investigation 89 (3): 824–833. doi:10.1172/JCI115661. PMC 442927. PMID 1541675.
- Camastra, S.; Bonora, E.; Del Prato, S.; Rett, K.; Weck, M.; Ferrannini, E. (1999). "Effect of obesity and insulin resistance on resting and glucose-induced thermogenesis in man. EGIR (European Group for the Study of Insulin Resistance)". International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 23 (12): 1307–1313. doi:10.1038/sj.ijo.0801072. PMID 10643689.
- Clegg, M. E.; Golsorkhi, M.; Henry, C. J. (2012). "Combined medium-chain triglyceride and chilli feeding increases diet-induced thermogenesis in normal-weight humans". European Journal of Nutrition. doi:10.1007/s00394-012-0463-9. PMID 23179202.
- JKeogh, J. B.; Lau, C. W. H.; Noakes, M.; Bowen, J.; Clifton, P. M. (2006). "Effects of meals with high soluble fibre, high amylose barley variant on glucose, insulin, satiety and thermic effect of food in healthy lean women". European Journal of Clinical Nutrition 61 (5): 597–604. doi:10.1038/sj.ejcn.1602564. PMID 17164830.
- Reed, G. W.; Hill, J. O. (1996). "Measuring the thermic effect of food". The American journal of clinical nutrition 63 (2): 164–169. PMID 8561055.
- Postprandial energy expenditure in whole-food and processed-food meals: implications for daily energy expenditure
|Citric Acid Cycle Metabolic Pathway|
|Acetyl-CoA||NADH + H+||NAD+||H2O||FADH2||FAD||CoA + ATP(GTP)||Pi + ADP(GDP)|
|+||H2O||NADH + H+ + CO2|
|H2O||H2O||NAD(P)+||NAD(P)H + H+||CO2|