Thiamine-diphosphate kinase

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thiamin diphosphate kinase
Identifiers
EC number 2.7.4.15
CAS number 9075-79-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a thiamine-diphosphate kinase is an enzyme involved in thiamine metabolism. It catalyzes the chemical reaction

thiamine diphosphate + ATP \rightleftharpoons thiamine triphosphate + ADP

Thus, the two substrates of this enzyme are ATP and thiamine diphosphate, whereas its two products are ADP and thiamine triphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:thiamine-diphosphate phosphotransferase. Other names in common use include ATP:thiamin-diphosphate phosphotransferase, TDP kinase, thiamin diphosphate kinase, thiamin diphosphate phosphotransferase, thiamin pyrophosphate kinase, thiamine diphosphate kinase, and protein bound thiamin diphosphate:ATP phosphoryltransferase.

See also[edit]

References[edit]

  • Itokawa Y, Cooper JR (1968). "The enzymatic synthesis of triphosphothiamin". Biochim. Biophys. Acta. 158 (1): 180–2. PMID 5661031. 
  • Kikuchi M and Ikawa T (Tokyo). "Presence of an enzyme mediating transfer of phosphate from thiamine triphosphate to ADP in germinating maize". Bot. Mag.: 193–205.  Check date values in: |date= (help)