Thiamine-triphosphatase

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thiamin triphosphatase
Identifiers
EC number 3.6.1.28
CAS number 9068-47-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO
thiamine triphosphatase
Identifiers
Symbol THTPA
Entrez 79178
HUGO 18987
RefSeq NM_024328
UniProt Q9BU02
Other data
Locus Chr. 14 q11.2

Thiamine-triphosphatase is an enzyme involved in thiamine metabolism. It catalyzes the chemical reaction

thiamine triphosphate + H2O \rightleftharpoons thiamine diphosphate + phosphate

This enzyme belongs to the family of acid anhydride hydrolases, specifically those acting on phosphorus-containing anhydrides. Its systematic name is thiamine triphosphate phosphohydrolase.

Structural studies[edit]

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2JMU.

See also[edit]

References[edit]

  • Hashitani Y, Cooper JR (1972). "The partial purification of thiamine triphosphatase from rat brain". J. Biol. Chem. 247 (7): 2117–9. PMID 4335862.