Thiamine-triphosphatase is an enzyme involved in thiamine metabolism. It catalyzes the chemical reaction
- thiamine triphosphate + H2O thiamine diphosphate + phosphate
This enzyme belongs to the family of acid anhydride hydrolases, specifically those acting on phosphorus-containing anhydrides. Its systematic name is thiamine triphosphate phosphohydrolase.
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2JMU.
- Hashitani Y, Cooper JR (1972). "The partial purification of thiamine triphosphatase from rat brain". J. Biol. Chem. 247 (7): 2117–9. PMID 4335862.