Thienopyridine

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Thienopyridines are a class of ADP receptor/P2Y12 inhibitors used for their anti-platelet activity.

[edit] Examples

These drugs include:

Prasugrel (Effient),^[1] Ticlopidine (Ticlid), Clopidogrel (Plavix).

[edit] References

^ Angiolillo DJ, Bates ER, Bass TA (August 2008). "Clinical profile of prasugrel, a novel thienopyridine". Am. Heart J. 156 (2 Suppl): S16–22. doi:10.1016/j.ahj.2008.06.005. PMID 18657682. http://linkinghub.elsevier.com/retrieve/pii/S0002-8703(08)00472-9.

Antithrombotics (thrombolytics)

Antiplatelet drugs

Glycoprotein IIb/IIIa inhibitors	Abciximab Eptifibatide Tirofiban

ADP receptor/P2Y₁₂ inhibitors	thienopyridines (Clopidogrel Prasugrel Ticlopidine) nucleotide/nucleoside analogs (Cangrelor Elinogrel Ticagrelor)

Prostaglandin analogue (PGI2)	Beraprost Prostacyclin Iloprost Treprostinil

COX inhibitors	Acetylsalicylic acid/Aspirin^# Aloxiprin Carbasalate calcium Indobufen Triflusal

Thromboxane inhibitors	thromboxane synthase inhibitors (Dipyridamole Picotamide) receptor antagonist (Terutroban^†)

Phosphodiesterase inhibitors	Cilostazol Dipyridamole Triflusal

Other	Cloricromen Ditazole

Vitamin K antagonists
(inhibit II, VII, IX, X)

other: Tioclomarol

Factor Xa inhibitors
(with some II inhibition)

Heparin group/ glycosaminoglycans/ (bind antithrombin)	low-molecular-weight heparin (Bemiparin Certoparin Dalteparin Enoxaparin Nadroparin Parnaparin Reviparin Tinzaparin) oligosaccharides (Fondaparinux Idraparinux) heparinoid (Danaparoid Sulodexide Dermatan sulfate)

Direct Xa inhibitors	xabans (Apixaban Betrixaban Edoxaban Otamixaban Rivaroxaban)

Direct thrombin (II) inhibitors

Other

Thrombolytic drugs/
fibrinolytics

plasminogen activators: r-tPA (Alteplase
Reteplase
Tenecteplase)
UPA (Urokinase
Saruplase)
Streptokinase^#
Anistreplase
Monteplase

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

cell/phys (coag, heme, immu, gran), csfs

rbmg/mogr/tumr/hist, sysi/epon, btst

drug (B1/2/3+5+6), btst, trns

This drug article relating to the blood and blood forming organs is a stub. You can help Wikipedia by expanding it.

Retrieved from "http://en.wikipedia.org/w/index.php?title=Thienopyridine&oldid=472572378"

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