Thiobarbital

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Thiobarbital
Thiobarbital.svg
Systematic (IUPAC) name
5,5-diethyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Clinical data
  •  ?
  •  ?
?
Pharmacokinetic data
Bioavailability ?
Metabolism ?
Half-life ?
Excretion ?
Identifiers
77-32-7 N
??
PubChem CID 667509
DrugBank ? N
ChemSpider 580885 YesY
Chemical data
Formula C8H12N2O2S
200.259
 N (what is this?)  (verify)

Thiobarbital is a drug which is a barbiturate derivative. It is the thiobarbiturate analogue of barbital.

Synthesis[edit]

Thiobarbital synthesis:[1][2]

It is of note that although the drug can be prepared by the above route (cf eg thialbarbital), rxn of barbital with phosphorus pentasulfide constitutes an alternative route to thiobarbital.

References[edit]

  1. ^ Fischer, E.; Dilthey, A. (1904). "Ueber C-Dialkylbarbitursäuren und über die Ureïde der Dialkylessigsäuren". Justus Liebig's Annalen der Chemie 335 (3): 334. doi:10.1002/jlac.19043350303.  edit
  2. ^ Carrington, H. C. (1944). "45. The action of phosphorus pentasulphide on barbituric acids". Journal of the Chemical Society (Resumed): 124. doi:10.1039/JR9440000124.  edit