|Jmol-3D images||Image 1|
| (what is: / ?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Thiocyanate (also known as rhodanide) is the anion [SCN]−. It is the conjugate base of thiocyanic acid. Common derivatives include the colourless salts potassium thiocyanate and sodium thiocyanate. Organic compounds containing the functional group SCN are also called thiocyanates. Mercury(II) thiocyanate was formerly used in pyrotechnics.
Thiocyanate is analogous to the cyanate ion, [OCN]−, wherein oxygen is replaced by sulfur. [SCN]− is one of the pseudohalides, due to the similarity of its reactions to that of halide ions. Thiocyanate used to be known as rhodanide (from a Greek word for rose) because of the red colour of its complexes with iron. Thiocyanate is produced by the reaction of elemental sulfur or thiosulfate with cyanide:
- 8 CN− + S8 → 8 SCN−
- CN− + S2O32− → SCN− + SO32−
Structure, bonding and coordination chemistry 
Thiocyanate shares its negative charge approximately equally between sulfur and nitrogen. As a consequence, thiocyanate can act as a nucleophile at either sulfur or nitrogen — it is an ambidentate ligand. [SCN]− can also bridge two (M−SCN−M) or even three metals (>SCN− or −SCN<). Experimental evidence leads to the general conclusion that class A metals (hard acids) tend to form N-bonded thiocyanate complexes, whereas class B metals (soft acids) tend to form S-bonded thiocyanate complexes. Other factors, e.g. kinetics and solubility, are sometimes involved, and linkage isomerism can occur, for example [Co(NH3)5(NCS)]Cl2 and [Co(NH3)5(SCN)]Cl2.
Organic thiocyanates 
Organic and transition metal derivatives of the thiocyanate ion can exist as "linkage isomers." In thiocyanates, the organic group (or metal ion) is attached to sulfur: R−S−C≡N has a S-C single bond and a C-N triple bond. In isothiocyanates, the substituent is attached to nitrogen: R−N=C=S has a S-C double bond and a C-N double bond:
Test for iron(III) 
Biological chemistry of thiocyanate in medicine 
Thiocyanate is known to be an important part in the biosynthesis of hypothiocyanite by a lactoperoxidase. Thus the complete absence of thiocyanate or reduced thiocyanate in the human body, (e.g., cystic fibrosis) is damaging to the human host defense system. Thiocyanate is a potent competitive inhibitor of the thyroid sodium-iodide symporter.
- Greenwood, Norman N.; Earnshaw, Alan (1997). Chemistry of the Elements (2nd ed.). Butterworth–Heinemann. p. 326. ISBN 0080379419.
- Guy, R. G. (1977). "Syntheses and Preparative Applications of Thiocyanates". In Patai, S. Chemistry of Cyanates and Their Derivatives 2. New York: John Wiley.
- Pedemonte, N.; Caci, E.; Sondo, E.; Caputo, A.; Rhoden, K.; Pfeffer, U.; di Candia, M.; Bandettini, R.; Ravazzolo, R.; Zegarra-Moran, O.; Galietta, L. J. (2007). "Thiocyanate Transport in Resting and IL-4-Stimulated Human Bronchial Epithelial Cells: Role of Pendrin and Anion Channels" (pdf). Journal of Immunology 178 (8): 5144–5153. PMID 17404297.
- Conner, G. E.; Wijkstrom-Frei, C.; Randell, S. H.; Fernandez, V. E.; Salathe, M. (2007). "The Lactoperoxidase System Links Anion Transport to Host Defense in Cystic Fibrosis" (pdf). FEBS Letters 581 (2): 271–278. doi:10.1016/j.febslet.2006.12.025. PMC 1851694. PMID 17204267.
- White, W. E.; Pruitt, K. M.; Mansson-Rahemtulla, B. (1983). "Peroxidase-Thiocyanate-Peroxide Antibacterial System Does not Damage DNA" (pdf). Antimicrobial Agents and Chemotherapy 23 (2): 267–272. PMC 186035. PMID 6340603.
- Thomas, E. L.; Aune, T. M. (1978). "Lactoperoxidase, Peroxide, Thiocyanate Antimicrobial System: Correlation of Sulfhydryl Oxidation with Antimicrobial Action" (pdf). Infection and Immunity 20 (2): 456–463. PMC 421877. PMID 352945.
- Childers, M.; Eckel, G.; Himmel, A.; Caldwell, J. (2007). "A new Model of Cystic Fibrosis Pathology: Lack of Transport of Glutathione and its Thiocyanate Conjugates". Medical Hypotheses 68 (1): 101–112. doi:10.1016/j.mehy.2006.06.020. PMID 16934416.
- Minarowski, Ł.; Sands, D.; Minarowska, A.; Karwowska, A.; Sulewska, A.; Gacko, M.; Chyczewska, E. (2008). "Thiocyanate concentration in saliva of cystic fibrosis patients" (pdf). Folia Histochemica et Cytobiologica 46 (2): 245–246. doi:10.2478/v10042-008-0037-0. PMID 18519245.
- Moskwa, P.; Lorentzen, D.; Excoffon, K. J.; Zabner, J.; McCray, P. B. Jr.; Nauseef, W. M.; Dupuy, C.; Bánfi, B. (2007). "A Novel Host Defense System of Airways is Defective in Cystic Fibrosis" (pdf). American Journal of Respiratory and Critical Care Medicine 175 (2): 174–183. doi:10.1164/rccm.200607-1029OC. PMC 2720149. PMID 17082494.
- Xu, Y.; Szép, S.; Lu, Z. (2009). "The antioxidant role of thiocyanate in the pathogenesis of cystic fibrosis and other inflammation-related diseases" (pdf). Proceedings of the National Academy of Science U.S.A. 106 (48): 20515–20519. Bibcode:2009PNAS..10620515X. doi:10.1073/pnas.0911412106. PMC 2777967. PMID 19918082.
- Braverman LE; He X; Pino S; et. al (2005). "The effect of perchlorate, thiocyanate, and nitrate on thyroid function in workers exposed to perchlorate long-term". J Clin Endocrinol Metab. 90 (2): 700–706. PMID 15572417.