Thioperamide

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Thioperamide
Thioperamide.svg
Systematic (IUPAC) name
N-Cyclohexyl-4-(1H-imidazol-4-yl)piperidine-1-carbothioamide
Clinical data
Legal status
?
Identifiers
CAS number 106243-16-7 N
ATC code None
PubChem CID 3035905
IUPHAR ligand 1267
ChemSpider 2300031 YesY
ChEMBL CHEMBL260374 YesY
Chemical data
Formula C15H24N4S 
Mol. mass 292.44 g/mol
 N (what is this?)  (verify)

Thioperamide is a potent HRH4 antagonist and selective HRH3 antagonist capable of crossing the blood–brain barrier.[1] It was used by Jean-Charles Schwartz in his early experiments regarding the H3 receptor.[2] Thioperamide was found to be an antagonist of histamine autoreceptors, which negatively regulate the release of histamine, and enhances the activity of histaminergic neurons by blocking autoreceptors, leading to greater release of histamine.

See also[edit]

References[edit]

  1. ^ "IUPHAR Database | Ligand Summary | thioperamide". 
  2. ^ Schwartz, Jean-Charles. The histamine H3 receptor: from discovery to clinical trials with pitolisant. BPJ 2011 May [1]