|Systematic (IUPAC) name|
|Mol. mass||292.44 g/mol|
| (what is this?)
Thioperamide is a potent and selective histamine H3 antagonist that is capable of crossing the blood–brain barrier. Thioperamide was used by Jean-Charles Schwartz in his early experiments regarding the H3 receptor. Thioperamide was found to be an antagonist of histamine autoreceptors, which negatively regulate the release of histamine; thioperamide enhances the activity of histaminergic neurons by blocking autoreceptors, leading to greater release of histamine.
- Schwartz, Jean-Charles. The histamine H3 receptor: from discovery to clinical trials with pitolisant. BPJ 2011 May 
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