Thioperamide

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Thioperamide
Thioperamide.svg
Systematic (IUPAC) name
N-Cyclohexyl-4-(1H-imidazol-4-yl)piperidine-1-carbothioamide
Clinical data
Legal status
?
Identifiers
CAS number 106243-16-7 N
ATC code None
PubChem CID 3035905
IUPHAR ligand 1267
ChemSpider 2300031 YesY
ChEMBL CHEMBL260374 YesY
Chemical data
Formula C15H24N4S 
Mol. mass 292.44 g/mol
 N (what is this?)  (verify)

Thioperamide is a potent HRH4 antagonist and selective HRH3 antagonist that is capable of crossing the blood–brain barrier.[1] Thioperamide was used by Jean-Charles Schwartz in his early experiments regarding the H3 receptor.[2] Thioperamide was found to be an antagonist of histamine autoreceptors, which negatively regulate the release of histamine; thioperamide enhances the activity of histaminergic neurons by blocking autoreceptors, leading to greater release of histamine.

See also[edit]

References[edit]

  1. ^ "IUPHAR DATABASE | LIGAND SUMMARY | thioperamide". 
  2. ^ Schwartz, Jean-Charles. The histamine H3 receptor: from discovery to clinical trials with pitolisant. BPJ 2011 May [1]