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Systematic (IUPAC) name
Clinical data
Trade names Navane
AHFS/ monograph
MedlinePlus a682867
Legal status
  • Prescription only
Routes Oral
Pharmacokinetic data
Metabolism Hepatic
Half-life 10-20 hours
CAS number 5591-45-7 YesY
ATC code N05AF04
PubChem CID 941651
IUPHAR ligand 212
DrugBank DB01623
ChemSpider 819430 YesY
UNII 7318FJ13YJ YesY
Chemical data
Formula C23H29N3O2S2 
Molecular mass 443.627 g/mol
 YesY (what is this?)  (verify)

Tiotixene (INN) or Thiothixene (USAN; Navane) is a typical antipsychotic drug of the thioxanthene class used in the treatment of psychoses like schizophrenia. It was introduced on July 24, 1967[1] by Pfizer.[2]

Thiothixene is the only first generation typical thioxanthene antipsychotic approved for use in the United States.


Thiothixene rx.png

See also:

  • J.F. Muren, B.M. Bloom, DE 1470157  (1963).
  • Chas. Pfizer & Co., BE 647066  (1964).
  • Muren, James F.; Bloom, Barry M. (1970). "Thioxanthene psychopharmacological agents. II. 9-(3-aminopropylidene)-N,N-dimethylthioxanthene-2-sulfonamides". Journal of Medicinal Chemistry 13 (1): 17–23. doi:10.1021/jm00295a005. PMID 5412109.  edit

See also[edit]


  1. ^
  2. ^ José Miguel Vela; Helmut Buschmann; Jörg Holenz; Antonio Párraga; Antoni Torrens (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. p. 520. ISBN 3-527-31058-4.